Endoplasmic Reticulum Oxidoreductase 1 (ERO1)

Endoplasmic Reticulum Oxidoreductase 1

Endoplasmic Reticulum Oxidoreductase 1 (ERO1) is a downstream component of the unfolded protein response (UPR) transcriptional regulation and leads to O2 consumption and H2O2 production. ERO1 is essential for maintaining cellular redox balance and adaptability, and ERO1 dysregulation can lead to adverse UPR responses and cell damage.

References:

[1]. Lin CY, et al. Identification and functional analysis of endoplasmic reticulum oxidoreductase 1 (ERO1) from the green mud crab Scylla paramamosain: The first evidence of ERO1 involved in invertebrate immune response. Fish Shellfish Immunol. 2023 Sep;140:108931. [Content Brief]

[2]. Sevier CS, et al. Ero1 and redox homeostasis in the endoplasmic reticulum. Biochim Biophys Acta. 2008 Apr;1783(4):549-56. [Content Brief]

[3]. Zito E. ERO1: A protein disulfide oxidase and H2O2 producer. Free Radic Biol Med. 2015 Jun;83:299-304. [Content Brief]

Endoplasmic Reticulum Oxidoreductase 1 (ERO1) Inhibitors (3)

Endoplasmic Reticulum Oxidoreductase 1 (ERO1) Related Products (3):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-12837

EN460	Inhibitor	99.73%
EN460 is a selective endoplasmic reticulum oxidation 1 (ERO1) inhibitor. EN460 (IC₅₀ of 1.9 μM) interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation.

HY-14852

Tafamidis	Inhibitor	99.89%
Tafamidis is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC₅₀s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis.

HY-148520

QM295	Inhibitor	99.32%
QM295 is an endoplasmic reticulum oxidation 1 (ERO1) inhibitor with selectively reversible thiol reactivity. QM295 can be used for the research of endoplasmic reticulum stress.

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