1-PalMitoyl-2-arachidoyllecithin-d₉-1  (Synonyms: 1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine-d₉-1; PAPC-d₉-1; PC(16:0/20:4)-d₉-1)

1-PalMitoyl-2-arachidoyllecithin-d₉-1 (1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine-d₉-1) is deuterium labeled 1-PalMitoyl-2-arachidoyllecithin. 1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PC (PAPC) is a phospholipid containing palmitic acid (16:0) and arachidonic acid (20:4) at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. PAPC is oxidized in vivo, and its oxidation products are involved in chronic inflammation and vascular disease. PAPC has been used to study signaling of oxidized phospholipids. Levels of PAPC are decreased in isolated human multiple myeloma cells^[1].

791.14

C₄₄H₇₁D₉NO₈P

1872379-11-7

35418-58-7

O=C(OC[C@H](COP(OCC[N+](C)(C)C)([O-])=O)OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)CCCCCCCCCCCC([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Gugiu, et al. Protein targets of oxidized phospholipids in endothelial cells. J. Lipid Res. 49, 510-520 (2008).