2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 12,13-DiHOME

12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±)12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±)12,13-DiHOME can be used for research of metabolic disorders.

For research use only. We do not sell to patients.

12,13-DiHOME Chemical Structure

12,13-DiHOME Chemical Structure

CAS No. : 263399-35-5

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500 μg（318.01 μM * 5 mL in Methyl acetate） USD 1300 In-stock
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Based on 1 publication(s) in Google Scholar

12,13-DiHOME Related Antibodies

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Description

12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±)12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±)12,13-DiHOME can be used for research of metabolic disorders[1].

In Vivo

12,13-DiHOME (1 μg/kg; retro-orbitally injection; once daily for 2 weeks) acutely decreases levels of serum triglycerides in mice with high-fat diet model, and increases BAT uptake to defend cold[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice fed a high-fat diet[1]
Dosage: 1 μg/kg
Administration: Retro-orbitally injection; once daily for 2 weeks
Result: Displayed no effects on body weight, glucose tolerance or circulating nonesterified FA.
Increased BAT-specific lipid uptake and improved oral lipid tolerance.
Increased radiolabeled FA uptake (Fig. 3f) and glucose uptake.
Animal Model: To explore the biosynthesis of (±)12, 13-dihome in mice in vivo[1]
Dosage:
Administration: 7-d cold challenge in mice: mice treated with norepinephrine (NE) for 30 min and exposed to 4°C-cold for 1 h
Result: Result: Increased in the circulation of male mice exposed to cold, but not female mice. And also, the enzymes producing 12,13-diHOME were uniquely induced in BAT by cold stimulation.
Molecular Weight

314.46

Formula

C18H34O4
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCCC(C(C/C=C\CCCCCCCC(O)=O)O)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (239 KB)

Handling Instructions (2659 KB)
References
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12,13-DiHOME Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

12,13-DiHOME263399-35-5Endogenous MetaboliteInhibitorinhibitorinhibit

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