16-epi-Latrunculin B

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16-epi-latrunculin B is anticancer agent, which can inhibit the growth of HeLa cells with IC₅₀ value of 3.9 uM. 16-epi-latrunculin B has antiviral activity against HSV-1 (ED₅₀ of 1 µg/mL).

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16-epi-Latrunculin B Chemical Structure

CAS No. : 444911-05-1

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Other Forms of 16-epi-Latrunculin B:

Latrunculin B Get quote

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Biological Activity
Purity & Documentation
References
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Description

16-epi-latrunculin B is anticancer agent, which can inhibit the growth of HeLa cells with IC₅₀ value of 3.9 uM^[1]. 16-epi-latrunculin B has antiviral activity against HSV-1 (ED₅₀ of 1 µg/mL)^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	38 μM Compound: 3	Cytotoxicity against human HCT116 cells after 3 days by trypan blue assay Cytotoxicity against human HCT116 cells after 3 days by trypan blue assay	[PMID: 18942825]
MDA-MB-435	IC₅₀	17 μM Compound: 3	Cytotoxicity against human MDA-MB-435 cells 48 hrs by SRB assay Cytotoxicity against human MDA-MB-435 cells 48 hrs by SRB assay	[PMID: 18942825]

Molecular Weight

395.51

Formula

C₂₀H₂₉NO₅S

CAS No.

444911-05-1

SMILES

O=C1SC[C@H]([C@]2(O)O[C@]3([H])CC[C@H](C)/C=C\CC/C(C)=C\C(O[C@@](C3)([H])C2)=O)N1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Diaa T A Youssef, et al. Magnificines A and B, Antimicrobial Marine Alkaloids Featuring a Tetrahydrooxazolo[3,2-a]azepine-2,5( 3H,6H)-dione Backbone from the Red Sea Sponge Negombata magnifica. Mar Drugs. 2021 Apr 12;19(4):214. [Content Brief]

[2]. Thomas R Hoye, et al. Toward computing relative configurations: 16-epi-latrunculin B, a new stereoisomer of the actin polymerization inhibitor latrunculin B. J Am Chem Soc. 2002 Jun 26;124(25):7405-10. [Content Brief]