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2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone 

Cat. No.: HY-N8796
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2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a dihydrochalcone compound isolated from Iryanthera juruensis Warb. 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a major cytotoxic metabolite when tested against a panel of cancer cell lines.

For research use only. We do not sell to patients.

2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone Chemical Structure

2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone Chemical Structure

CAS No. : 75679-58-2

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Description

2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a dihydrochalcone compound isolated from Iryanthera juruensis Warb. 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a major cytotoxic metabolite when tested against a panel of cancer cell lines[1].

Cellular Effect
Cell Line Type Value Description References
DU-145 GI50
> 206 μM
Compound: 1
Cytotoxicity against human DU145 cells after 48 hrs
Cytotoxicity against human DU145 cells after 48 hrs
[PMID: 18798609]
HT-29 GI50
> 206 μM
Compound: 1
Cytotoxicity against human HT29 cells after 48 hrs
Cytotoxicity against human HT29 cells after 48 hrs
[PMID: 18798609]
K562 GI50
22.8 μM
Compound: 1
Cytotoxicity against human K562 cells after 48 hrs
Cytotoxicity against human K562 cells after 48 hrs
[PMID: 18798609]
M14 GI50
109.2 μM
Compound: 1
Cytotoxicity against human M14 cells after 48 hrs
Cytotoxicity against human M14 cells after 48 hrs
[PMID: 18798609]
MCF7 GI50
65.5 μM
Compound: 1
Cytotoxicity against human MCF7 cells after 48 hrs
Cytotoxicity against human MCF7 cells after 48 hrs
[PMID: 18798609]
NCI-H460 GI50
128 μM
Compound: 1
Cytotoxicity against human H460 cells after 48 hrs
Cytotoxicity against human H460 cells after 48 hrs
[PMID: 18798609]
NIH3T3 GI50
> 206 μM
Compound: 1
Cytotoxicity against BALB mouse 3T3 cells after 48 hrs
Cytotoxicity against BALB mouse 3T3 cells after 48 hrs
[PMID: 18798609]
PC-3 GI50
59.9 μM
Compound: 1
Cytotoxicity against human PC3 cells after 48 hrs
Cytotoxicity against human PC3 cells after 48 hrs
[PMID: 18798609]
Vero IC50
> 25 μM
Compound: 1
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 in african green monkey Vero cells after 120 hrs
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 in african green monkey Vero cells after 120 hrs
[PMID: 18798609]
Molecular Weight

302.32

Formula

C17H18O5

CAS No.
SMILES

O=C(C1=C(OC)C=C(O)C=C1O)CCC2=CC=C(OC)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone
Cat. No.:
HY-N8796
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