2. Apoptosis
  3. Apoptosis
  4. 2'-Hydroxyflavanone

2'-Hydroxyflavanone is a flavanone that can inhibit cancer cell proliferation, induce apoptosis, and reduce inflammation. 2'-Hydroxyflavanone shows inhibitory effect on platelet aggregation caused by two inducers with IC50s 47.8 μM arachidonic acid (AA) and 147.2 μM aenosine diphosphate (ADP).

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2'-Hydroxyflavanone Chemical Structure

2'-Hydroxyflavanone Chemical Structure

CAS No. : 17348-76-4

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2'-Hydroxyflavanone Related Antibodies

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Description

2'-Hydroxyflavanone is a flavanone that can inhibit cancer cell proliferation, induce apoptosis, and reduce inflammation. 2'-Hydroxyflavanone shows inhibitory effect on platelet aggregation caused by two inducers with IC50s 47.8 μM arachidonic acid (AA) and 147.2 μM aenosine diphosphate (ADP)[1].

Cellular Effect
Cell Line Type Value Description References
DU-145 IC50
4.11 μM
Compound: 1; 2'-HF
Antiproliferative activity against human DU145 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
Antiproliferative activity against human DU145 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
[PMID: 30189396]
J774.A1 IC50
71.3 μM
Compound: 1
Inhibition of LPS-induced nitric oxide production in mouse J774A.1 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay
Inhibition of LPS-induced nitric oxide production in mouse J774A.1 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay
[PMID: 25824662]
J774.A1 IC50
71.3 μM
Compound: 1
Inhibition of IL-1beta production in mouse J774A.1 cells incubated for 12 hrs by sandwich immunoassay
Inhibition of IL-1beta production in mouse J774A.1 cells incubated for 12 hrs by sandwich immunoassay
[PMID: 25824662]
J774.A1 IC50
71.3 μM
Compound: 1
Inhibition of TNFalpha production in mouse J774A.1 cells incubated for 6 hrs by sandwich immunoassay
Inhibition of TNFalpha production in mouse J774A.1 cells incubated for 6 hrs by sandwich immunoassay
[PMID: 25824662]
LNCaP IC50
5.45 μM
Compound: 1; 2'-HF
Antiproliferative activity against human LNCAP cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
Antiproliferative activity against human LNCAP cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
[PMID: 30189396]
PC-3 IC50
2.56 μM
Compound: 1; 2'-HF
Antiproliferative activity against human PC3 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
Antiproliferative activity against human PC3 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
[PMID: 30189396]
RAW264.7 IC50
71.3 μM
Compound: 1
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay
[PMID: 25824662]
RAW264.7 IC50
71.3 μM
Compound: 1
Inhibition of IL-1beta production in mouse RAW264.7 cells incubated for 12 hrs by sandwich immunoassay
Inhibition of IL-1beta production in mouse RAW264.7 cells incubated for 12 hrs by sandwich immunoassay
[PMID: 25824662]
RAW264.7 IC50
71.3 μM
Compound: 1
Inhibition of TNFalpha production in mouse RAW264.7 cells incubated for 6 hrs by sandwich immunoassay
Inhibition of TNFalpha production in mouse RAW264.7 cells incubated for 6 hrs by sandwich immunoassay
[PMID: 25824662]
Molecular Weight

240.25

Formula

C15H12O3
CAS No.
SMILES

O=C1CC(C2=CC=CC=C2O)OC3=CC=CC=C13
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2'-Hydroxyflavanone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-Hydroxyflavanone17348-76-4Apoptosisarachidonic acidaenosine diphosphateplatelet aggregationInhibitorinhibitorinhibit

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