2. Epigenetics
  3. Epigenetic Reader Domain
  4. (2S,3R)-LP99

(2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion.

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(2S,3R)-LP99 Chemical Structure

(2S,3R)-LP99 Chemical Structure

CAS No. : 1808948-28-8

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Based on 1 publication(s) in Google Scholar

(2S,3R)-LP99 Related Antibodies

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Description

(2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1].

IC50 & Target[1]

BRD7

 

BRD9

99 nM (Kd)

In Vitro

(2S,3R)-LP99 (compound 60) (0-100 µM) inhibits the expression of IL6 in LPS-stimulated (100 ng/mL) THP-1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(2S,3R)-LP99 Related Antibodies
Molecular Weight

516.05

Formula

C26H30ClN3O4S
CAS No.
SMILES

CC(CS(=O)(N[C@@H]([C@@H](N1C2=CC3=C(C(C)=CC(N3C)=O)C=C2)C4=CC=C(C=C4)Cl)CCC1=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(2S,3R)-LP99 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(2S,3R)-LP991808948-28-8Epigenetic Reader Domainbromodomain-containingacetylated histonesselectivepro-inflammatory cytokineIL6THP-1 cellsInhibitorinhibitorinhibit

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