2. NF-κB
  3. NF-κB
  4. 3-(2-Hydroxyethyl) thio withaferin A

3-(2-Hydroxyethyl) thio withaferin A is a Withaferin A derivative. Withaferin A, a steroidal lactone, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

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3-(2-Hydroxyethyl) thio withaferin A Chemical Structure

3-(2-Hydroxyethyl) thio withaferin A Chemical Structure

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3-(2-Hydroxyethyl) thio withaferin A Related Antibodies

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Description

3-(2-Hydroxyethyl) thio withaferin A is a Withaferin A derivative. Withaferin A, a steroidal lactone, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding[1][2][3].

Molecular Weight

548.73

Formula

C30H44O7S
SMILES

C[C@H](C1OC(C(CO)=C(C)C1)=O)C2CCC3C4C[C@@H]5[C@]([C@@]6(C)C4CC[C@@]32C)(O5)[C@@H](O)[C@@H](SCCO)CC6=O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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3-(2-Hydroxyethyl) thio withaferin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-(2-Hydroxyethyl) thio withaferin ANF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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