3-Azaspiro[5.5]undecane hydrochloride (Synonyms: 4,4-Pentamethylenepiperidine hydrochloride)

Cat. No.: HY-107755 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

3-Azaspiro[5.5]undecane (4,4-Pentamethylenepiperidine) hydrochloride is an inhibitor targeting the WT influenza A virus M2 (A/M2), with an IC₅₀ of 1 μM.

For research use only. We do not sell to patients.

3-Azaspiro[5.5]undecane hydrochloride Chemical Structure

CAS No. : 1125-01-5

Size	Price	Stock
50 mg	USD 25	Ask For Quote & Lead Time
100 mg	USD 40	Ask For Quote & Lead Time
250 mg	USD 78	Ask For Quote & Lead Time
500 mg	USD 125	Ask For Quote & Lead Time
1 g	USD 200	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Purity & Documentation
References
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Description

3-Azaspiro[5.5]undecane (4,4-Pentamethylenepiperidine) hydrochloride is an inhibitor targeting the WT influenza A virus M2 (A/M2), with an IC₅₀ of 1 μM^[1].

IC₅₀ & Target

IC50: 1 μM (influenza A virus M2)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Oocyte	IC₅₀	1 μM Compound: 1	Inhibition of Influenza A Virus M2 proton channel expressed in Xenopus laevis oocytes after 2 mins by two-electrode patch clamp assay Inhibition of Influenza A Virus M2 proton channel expressed in Xenopus laevis oocytes after 2 mins by two-electrode patch clamp assay	[PMID: 21691418]

Molecular Weight

189.73

Formula

C₁₀H₂₀ClN

CAS No.

1125-01-5

Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.C12(CCNCC2)CCCCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (527.06 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2706 mL	26.3532 mL	52.7065 mL
5 mM	1.0541 mL	5.2706 mL	10.5413 mL
10 mM	0.5271 mL	2.6353 mL	5.2706 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (247 KB) HNMR (117 KB)

Handling Instructions (2659 KB)

References

[1]. Wang J, et al. Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus. ACS Med Chem Lett. 2011 Apr 14;2(4):307-312. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.2706 mL	26.3532 mL	52.7065 mL	131.7662 mL
	5 mM	1.0541 mL	5.2706 mL	10.5413 mL	26.3532 mL
	10 mM	0.5271 mL	2.6353 mL	5.2706 mL	13.1766 mL
	15 mM	0.3514 mL	1.7569 mL	3.5138 mL	8.7844 mL
	20 mM	0.2635 mL	1.3177 mL	2.6353 mL	6.5883 mL
	25 mM	0.2108 mL	1.0541 mL	2.1083 mL	5.2706 mL
	30 mM	0.1757 mL	0.8784 mL	1.7569 mL	4.3922 mL
	40 mM	0.1318 mL	0.6588 mL	1.3177 mL	3.2942 mL
	50 mM	0.1054 mL	0.5271 mL	1.0541 mL	2.6353 mL
	60 mM	0.0878 mL	0.4392 mL	0.8784 mL	2.1961 mL
	80 mM	0.0659 mL	0.3294 mL	0.6588 mL	1.6471 mL
	100 mM	0.0527 mL	0.2635 mL	0.5271 mL	1.3177 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

3-Azaspiro[5.5]undecane hydrochloride Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Azaspiro[5.5]undecane1125-01-54,4-PentamethylenepiperidineInfluenza VirusInhibitorinhibitorinhibit

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