4-(Aminomethyl)benzoic acid (Synonyms: Aminomethylbenzoic acid; α-Amino-p-toluic acid)

Cat. No.: HY-B1258 Purity: 99.99%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

4-(Aminomethyl)benzoic acid is a competitive inhibitor of PepT1 and has antifibrinolytic activity.

For research use only. We do not sell to patients.

4-(Aminomethyl)benzoic acid Chemical Structure

CAS No. : 56-91-7

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 28	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 28	In-stock	Estimated Time of Arrival: December 31
Solid
1 g	USD 25	In-stock	Estimated Time of Arrival: December 31
5 g	USD 40	In-stock	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

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Other Forms of 4-(Aminomethyl)benzoic acid:

4-(Aminomethyl)benzoic acid (Standard) Get quote

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Purity & Documentation
References
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Description

4-(Aminomethyl)benzoic acid is a competitive inhibitor of PepT1 and has antifibrinolytic activity^[1].

In Vivo

4-AMBA (10 mM per rat, intraduodenal perfusion, single dose) blocks the inhibition of gastric motility induced by protein hydrolysates in a healthy Sprague-Dawley rat model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Healthy Sprague-Dawley rat model (weighing 200 –300 g)^[1]
Dosage:	10 mM
Administration:	Intraduodenal perfusion (i.d.), single dose
Result:	Blocked the inhibition of gastric motility induced by protein hydrolysates.

Molecular Weight

151.16

Formula

C₈H₉NO₂

CAS No.

56-91-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=C(CN)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 9.09 mg/mL (60.13 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.6155 mL	33.0775 mL	66.1551 mL
5 mM	1.3231 mL	6.6155 mL	13.2310 mL
10 mM	0.6616 mL	3.3078 mL	6.6155 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 4.55 mg/mL (30.10 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.99%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (244 KB) HNMR (110 KB) RP-HPLC (225 KB)

Handling Instructions (2659 KB)

References

[1]. Darcel N P, et al. Activation of vagal afferents in the rat duodenum by protein digests requires PepT1[J]. The Journal of nutrition, 2005, 135(6): 1491-1495. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.6155 mL	33.0775 mL	66.1551 mL	165.3877 mL
	5 mM	1.3231 mL	6.6155 mL	13.2310 mL	33.0775 mL
	10 mM	0.6616 mL	3.3078 mL	6.6155 mL	16.5388 mL
	15 mM	0.4410 mL	2.2052 mL	4.4103 mL	11.0258 mL
	20 mM	0.3308 mL	1.6539 mL	3.3078 mL	8.2694 mL
	25 mM	0.2646 mL	1.3231 mL	2.6462 mL	6.6155 mL
	30 mM	0.2205 mL	1.1026 mL	2.2052 mL	5.5129 mL
	40 mM	0.1654 mL	0.8269 mL	1.6539 mL	4.1347 mL
	50 mM	0.1323 mL	0.6616 mL	1.3231 mL	3.3078 mL
	60 mM	0.1103 mL	0.5513 mL	1.1026 mL	2.7565 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

4-(Aminomethyl)benzoic acid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-(Aminomethyl)benzoic acid56-91-7Aminomethylbenzoic acid α-Amino-p-toluic acidAmino Acid DerivativesHealthy Sprague-Dawley rat modelAntifibrinolytic activityInhibitorinhibitorinhibit

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