2. GPCR/G Protein
  3. Adenosine Receptor
  4. 5'-(N-Cyclopropyl)carboxamidoadenosine

5'-(N-Cyclopropyl)carboxamidoadenosine (CPCA) is an adenosine A2 receptor agonist.

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5'-(N-Cyclopropyl)carboxamidoadenosine Chemical Structure

5'-(N-Cyclopropyl)carboxamidoadenosine Chemical Structure

CAS No. : 50908-62-8

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Based on 1 publication(s) in Google Scholar

5'-(N-Cyclopropyl)carboxamidoadenosine Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Description

5'-(N-Cyclopropyl)carboxamidoadenosine (CPCA) is an adenosine A2 receptor agonist[1].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
22.9 nM
Compound: 16
Agonist activity at human A2A adenosine receptor expressed in CHO cells assessed as stimulation of forskolin-induced cAMP accumulation after 30 mins
Agonist activity at human A2A adenosine receptor expressed in CHO cells assessed as stimulation of forskolin-induced cAMP accumulation after 30 mins
[PMID: 22486652]
PC-12 EC50
110 nM
Compound: 6
Potency against PC12 cell A2 adenosine receptor by adenylate cyclase activation
Potency against PC12 cell A2 adenosine receptor by adenylate cyclase activation
[PMID: 3018244]
Molecular Weight

320.30

Formula

C13H16N6O4
CAS No.
SMILES

O[C@H]([C@@H]1O)[C@](O[C@@H]1C(NC2CC2)=O)([H])N3C4=NC=NC(N)=C4N=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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5'-(N-Cyclopropyl)carboxamidoadenosine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5'-(N-Cyclopropyl)carboxamidoadenosine50908-62-8Adenosine ReceptorP1 receptorInhibitorinhibitorinhibit

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5'-(N-Cyclopropyl)carboxamidoadenosine
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