6-O-Methacrylate 

6-O-Methacrylate, a trilobolide, is isolated from the leaves of Wedelia trilobata. 6-O-Methacrylate displays marked antimalarial activity, with IC₅₀ of 8.9 μg/mL against P. falciparum parasite. 6-O-Methacrylate also has anti-tobacco mosaic virus (TMV) activity^[1][2].

6-O-Methacrylate (10 μg/mL) shows anti-TMV activities in the pretreated tobacco plants with inhibition rate of 59.6%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

450.48

C₂₃H₃₀O₉

950685-51-5

C[C@]12[C@@]([C@](O)(CC[C@H]2OC(C)=O)C)([H])[C@@H]([C@]3([H])[C@](OC(C3=C)=O)([H])[C@H]1OC(C)=O)OC(C(C)=C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. That QT, et, al. Wedelolides A and B: novel sesquiterpene delta-lactones, (9R)-eudesman-9,12-olides, from Wedelia trilobata. J Org Chem. 2007 Sep 14;72(19):7102-5.  [Content Brief]

  [2]. Li Y, et, al. Eudesmanolides from Wedelia trilobata (L.) Hitchc. as potential inducers of plant systemic acquired resistance. J Agric Food Chem. 2013 Apr 24;61(16):3884-90.  [Content Brief]