2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 7-Methylguanine

7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method.

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7-Methylguanine Chemical Structure

7-Methylguanine Chemical Structure

CAS No. : 578-76-7

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Based on 1 publication(s) in Google Scholar

Other Forms of 7-Methylguanine:

7-Methylguanine Related Antibodies

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Description

7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method.

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

165.15

Formula

C6H7N5O
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1NC(N)=NC2=C1N(C)C=N2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

1M NaOH : 100 mg/mL (605.51 mM; Need ultrasonic)

H2O : 4.72 mg/mL (28.58 mM; ultrasonic and adjust pH to 11 with 1 M NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0551 mL 30.2755 mL 60.5510 mL
5 mM 1.2110 mL 6.0551 mL 12.1102 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / 1M NaOH 1 mM 6.0551 mL 30.2755 mL 60.5510 mL 151.3775 mL
5 mM 1.2110 mL 6.0551 mL 12.1102 mL 30.2755 mL
10 mM 0.6055 mL 3.0276 mL 6.0551 mL 15.1378 mL
15 mM 0.4037 mL 2.0184 mL 4.0367 mL 10.0918 mL
20 mM 0.3028 mL 1.5138 mL 3.0276 mL 7.5689 mL
25 mM 0.2422 mL 1.2110 mL 2.4220 mL 6.0551 mL
1M NaOH 30 mM 0.2018 mL 1.0092 mL 2.0184 mL 5.0459 mL
40 mM 0.1514 mL 0.7569 mL 1.5138 mL 3.7844 mL
50 mM 0.1211 mL 0.6055 mL 1.2110 mL 3.0276 mL
60 mM 0.1009 mL 0.5046 mL 1.0092 mL 2.5230 mL
80 mM 0.0757 mL 0.3784 mL 0.7569 mL 1.8922 mL
100 mM 0.0606 mL 0.3028 mL 0.6055 mL 1.5138 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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7-Methylguanine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Methylguanine578-76-7Endogenous MetaboliteInhibitorinhibitorinhibit

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