8-Azido-ADP disodium 

8-Azido-ADP (disodium) is a covalent-binding inhibitor of mitochondrial adenine nucleotide translocation. 8-Azido-ADP (disodium) causes irreversible inhibition of adenine nucleotide exchange in a light-dependent reaction. 8-Azido-ADP (disodium) inhibits the normal state 4 → 3 transitions of mitochondrial respiration induced by ADP^[1]. 8-Azido-ADP (disodium) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Adenine nucleotide^[1]

512.18

C₁₀H₁₂N₈Na₂O₁₀P₂

102185-14-8

O[C@@H]([C@H]([C@H](N1C(N=[N+]=[N-])=NC2=C(N=CN=C21)N)O3)O)[C@H]3COP(OP(O)(O[Na])=O)(O[Na])=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. SchHafer G, et al. 8-azido-ADP, a covalent-binding inhibitor of mitochondrial adenine nucleotide translocation. FEBS Lett. 1976 Apr 15;64(1):185-9.  [Content Brief]