2. Immunology/Inflammation
  3. NO Synthase
  4. 8A8

8A8 is a potent proinflammatory factor NO inhibitor with an IC50 of 4.7 μM. 8A8 also significantly inhibits LPS-induced HaCat cell proliferation.

For research use only. We do not sell to patients.

8A8 Chemical Structure

8A8 Chemical Structure

CAS No. : 2766594-12-9

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8A8 Related Antibodies

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Description

8A8 is a potent proinflammatory factor NO inhibitor with an IC50 of 4.7 μM. 8A8 also significantly inhibits LPS-induced HaCat cell proliferation[1].

In Vitro

Low concentrations of compound 8A8 (2.5 μM; RAW 264.7 cells) could significantly down-regulate IL-6 and TNF-α in cellular emotional intelligence, IL-6 and TNF-α are only half of those after LPS treatment at 5 μM, and IL-6 and TNF-α in cell supernatants were only a quarter of those after LPS treatment after high concentration compound 8A8 (10 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

8A8 Related Antibodies
Molecular Weight

799.06

Formula

C36H37BrClN5O9
CAS No.
SMILES

COC1=CC(OC)=C2C(C(OCC3=CN(N=N3)CCN4CCN(CC4)C(C5=CC(Br)=CC=C5Cl)=O)=C(OC2=C1)C6=CC(OC)=C(C(OC)=C6)OC)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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8A8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8A82766594-12-9NO SynthaseNitric oxide synthasesNOSIL-6TNF-αRAW 264.7 cellsLPSHaCat proliferationInhibitorinhibitorinhibit

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HY-115927
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