2. NF-κB
  3. NF-κB
  4. 8α-Hydroxyhirsutinolide

8α-Hydroxyhirsutinolide is a sesquiterpene lactone. 8α-Hydroxyhirsutinolide inhibits TNF-α-induced NF-κB activity (IC50: 1.9 μM) and NO production. 8α-Hydroxyhirsutinolide can be isolated from Vernonia cinerea.

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8α-Hydroxyhirsutinolide Chemical Structure

8α-Hydroxyhirsutinolide Chemical Structure

CAS No. : 1394156-45-6

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8α-Hydroxyhirsutinolide Related Antibodies

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Description

8α-Hydroxyhirsutinolide is a sesquiterpene lactone. 8α-Hydroxyhirsutinolide inhibits TNF-α-induced NF-κB activity (IC50: 1.9 μM) and NO production. 8α-Hydroxyhirsutinolide can be isolated from Vernonia cinerea[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
1.9 μM
Compound: 2
Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells after 6 hrs by luciferase reporter gene assay
Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells after 6 hrs by luciferase reporter gene assay
[PMID: 22850207]
RAW264.7 IC50
24.7 μM
Compound: 2
Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method
Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method
[PMID: 22850207]
Molecular Weight

296.32

Formula

C15H20O6
CAS No.
SMILES

OCC1=C2/C(OC1=O)=C\[C@@]3(O[C@]([C@@H](C[C@@H]2O)C)(CC3)O)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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8α-Hydroxyhirsutinolide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8α-Hydroxyhirsutinolide1394156-45-6NF-κBNuclear factor-κBNuclear factor-kappaBVernonia cinereaAsteraceaeSesquiterpene lactoneanti-inflammatoryNOLPSAnti-Inflammatory AgentInhibitorinhibitorinhibit

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