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  4. 9-cis-β-Carotene

9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. 9-cis-β-Carotene inhibits photoreceptor degeneration and restores retinal function in vivo. 9-cis-β-Carotene has the potential for the study of congenital stationary night blindness and fundus albipunctatus.

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9-cis-β-Carotene Chemical Structure

9-cis-β-Carotene Chemical Structure

CAS No. : 13312-52-2

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Based on 1 publication(s) in Google Scholar

9-cis-β-Carotene Related Antibodies

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Description

9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. 9-cis-β-Carotene inhibits photoreceptor degeneration and restores retinal function in vivo. 9-cis-β-Carotene has the potential for the study of congenital stationary night blindness and fundus albipunctatus[1].
In Vitro

9-cis-β-Carotene (1 μM; 18 hours) formulates with the Miglyol 810 and the“antioxidant mix” is incubated to eye cups. The eye cups are isolated from the neuro-retina attached to the underlying RPE tissue from RPE65rd12 mouse. It prevents S- and M-cones degeneration and leads to over 2- and 9- fold higher m-opsin and s-opsin positive staining compares to the control group[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9-cis-β-Carotene Related Antibodies
In Vivo

In a mouse model of retinoid cycle defect, RPE65rd12. Mice with an extract of Dunaliella Bardawil algae rich in 9-cis-β-Carotene (9CBC) rescues retinal function and preserves cone structure by oral administration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

536.87

Formula

C40H56
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(/C=C/C=C(\C=C\C2=C(C)CCCC2(C)C)C)C)C(C)(C)CCC1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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9-cis-β-Carotene Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

9-cis-β-Carotene13312-52-2OthersEyecupS-coneopsinM-coneRPE65Rd12retinitispigmentosaBCMO1,fundusalbipunctatusInhibitorinhibitorinhibit

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