AMG 837

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AMG 837 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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AMG 837 Chemical Structure

CAS No. : 865231-46-5

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Other In-stock Forms of AMG 837:

AMG 837 calcium hydrate

Other Forms of AMG 837:

1 Publications Citing Use of MCE AMG 837

•Biomed Pharmacother. 2023 May.

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Purity & Documentation
References
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Description

AMG 837 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cellular Effect

Cell Line	Type	Value	Description	References
A9	EC₅₀	41 nM Compound: 2, AMG 837	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	[PMID: 24900872]
CHO	EC₅₀	0.013 μM Compound: AMG 837	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	[PMID: 26620255]
CHO	EC₅₀	0.06 μM Compound: 1, AMG-837	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	[PMID: 24900539]
CHO	EC₅₀	0.06 μM Compound: 1, AMG 837	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	[PMID: 24900707]
CHO	EC₅₀	0.08 μM Compound: AMG 837	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	[PMID: 26620255]
CHO	EC₅₀	104 nM Compound: 2, AMG 837	Agonist activity at human GPR40 expressed in CHO cells by aequorin assay Agonist activity at human GPR40 expressed in CHO cells by aequorin assay	[PMID: 24900872]
CHO	EC₅₀	8.8 μM Compound: AMG 837	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	[PMID: 26620255]
HEK293	EC₅₀	2.2 nM Compound: AMG-837	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	[PMID: 27994752]

Molecular Weight

438.44

Formula

C₂₆H₂₁F₃O₃

CAS No.

865231-46-5

SMILES

OC(C[C@H](C#CC)C1=CC=C(C=C1)OCC2=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Houze JB, et al. AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1267-70. [Content Brief]

[2]. Lin DC, et al. AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents. PLoS One. 2011;6(11):e27270. [Content Brief]

AMG 837 Related Classifications

Metabolic Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMG 837865231-46-5AMG837AMG-837Free Fatty Acid ReceptorFFARInhibitorinhibitorinhibit

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