2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Becampanel

Becampanel (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent.

For research use only. We do not sell to patients.

Becampanel Chemical Structure

Becampanel Chemical Structure

CAS No. : 188696-80-2

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Becampanel Related Antibodies

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Description

Becampanel (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent.

In Vitro

Becampanel is negative in a mouse lymphoma tk assay, which includes a 24 h treatment without S9. A weak micronucleus induction in vitro is found at the highest concentrations tested in V79 cells with S9[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Becampanel Related Antibodies
In Vivo

Becampanel is negative in the following in vivo studies, which includes the maximum tolerated doses of 320 mg/kg in mice and 2000 mg/kg in rats. Becampanel has no genotoxic potential in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

330.19

Formula

C10H11N4O7P
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1C(NC2=CC([N+]([O-])=O)=CC(CNCP(O)(O)=O)=C2N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
Animal Administration
[1]

The study protocol is in compliance with the corresponding OECD guideline. The test article is dissolved in 0.2 M NaHCO3. The dose-finding experiment with Becampanel shows that treatment of CD-1 mice by oral gavage with 450.5, 500 or 800 mg/kg, twice with an interval of 24 h, leads to strong signs of toxicity such as laboured breathing, ataxia, and strong sedation. At 320 mg/kg, the same symptoms are visible, but with less severity, and no animals die. On the basis of these results, doses of 32, 100 and 320 mg/kg are chosen for this micronucleus test. In the main experiment five male and five female mice are treated as described above and bone marrow is sampled 48 h after the first application. Nucleated cells are removed from the bone marrow samples using cellulose columns. The cells are loaded on poly-l-lysine coated glass slides by cytocentrifugation using a Shandon Cytospin stained with May Grunwald stain (5%) and Giemsa (14%). The slides are automatically evaluated with a LEITZ MIAS image analyser. No statistical analysis is performed since all values in the treated groups are≤the frequency of micronucleated polychromatic erythrocyte in the concurrent vehicle control group.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Becampanel Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Becampanel188696-80-2AMP 397AMP397AMP-397iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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