2. Anti-infection
  3. EBV HSV
  4. BRL44385

BRL44385 is a potent and selective inhibitor of the replication of herpes simplex virus types 1 and 2 (HSV-1 and HSV2), varicella zoster virus (VZV) and Epstein-Barr virus (EBV).

For research use only. We do not sell to patients.

BRL44385 Chemical Structure

BRL44385 Chemical Structure

CAS No. : 114778-60-8

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BRL44385 Related Antibodies

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Description

BRL44385 is a potent and selective inhibitor of the replication of herpes simplex virus types 1 and 2 (HSV-1 and HSV2), varicella zoster virus (VZV) and Epstein-Barr virus (EBV).

IC50 & Target[1]

HSV-1

 

HSV-2

 

In Vivo

BRL44385 is a selective antiherpesvirus agent. Following oral administration, BRL 55792 is very well absorbed and provides high and prolonged concentrations of BRL44385 in the blood. In mice 15 min and 60 min after administration of a single oral dose of BRL 55792, the concentrations of BRL44385 in the blood are considerably higher than those obtain after oral administration of either BRL44385 or BRL46720 and the bioavailability of BRL 44385 from oral BRL 55792 is 66% of that achieves with the same dose of the sodium salt of BRL44385 administered intravenously[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

225.20

Formula

C8H11N5O3
CAS No.
SMILES

O=C1N=C(N)NC2=C1N=CN2OCCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Animal Administration
[1]

Mice[1]
BRL44385 is administered as a single dose of 0.2 mmol/kg in 0.1 mL of 1% carboxymethylcellulose by oral gavage to female Balb/c mice weighing approximately 20 g. Food is withheld for 18 h prior to the start of the experiment. Blood is collected by cardiac puncture using heparinized syringes 15, 60, and 180 min after dosing. Equal volumes (0.2 mL) from three mice are pooled at each time point and 0.6 mL of 16% trichloroacetic acid is added. After centrifugation, 0.5 mL of supernatant is added to 0.1 mL of saturated aqueous NaHCO3 followed by the addition of 0.6 mL of 0.4 mM NH4OAc (pH 6.0) and the mixture analysed by HPLC.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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BRL44385 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRL44385114778-60-8BRL 44385BRL-44385EBVHSVEpstein-Barr VirusHerpes simplex virusInhibitorinhibitorinhibit

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HY-U00224
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