2. Apoptosis
  3. Bcl-2 Family
  4. Bak BH3

Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Bak BH3 Chemical Structure

Bak BH3 Chemical Structure

CAS No. : 300349-67-1

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Other Forms of Bak BH3:

Bak BH3 Related Antibodies

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  • Biological Activity

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Description

Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.

IC50 & Target[1]

Bcl-xL

 

In Vitro

Bak BH3 peptide antagonize the protective effects of microinjected Bcl-xL in α-Fas-treated HeLa cells, whereas a mutant Bak BH3 peptide that no longer binds Bcl-xL is inactive[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bak BH3 Related Antibodies
Molecular Weight

1724.90

Formula

C72H125N25O24
CAS No.
Sequence

Gly-Gln-Val-Gly-Arg-Gln-Leu-Ala-Ile-Ile-Gly-Asp-Asp-Ile-Asn-Arg
Sequence Shortening

GQVGRQLAIIGDDINR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Cell Assay
[1]

Cells are plated in complete DMEM in 96-well tissue culture plates at 4×103/well. After 24 h, cells are washed with PBS and treated with peptides (50 μM) in SF-DMEM. Cell viability is determined by staining unfixed cells with calcein AM/ethidium homodimer, followed by microscopic analysis of cell staining and cellular morphology on a Nikon Diaphot 300 inverted microscope equipped with a fluorescence module.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Bak BH3 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bak BH3300349-67-1Bak BH 3Bak BH-3Bcl-2 FamilyInhibitorinhibitorinhibit

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Bak BH3
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HY-P0300
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