2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Endogenous Metabolite Arginase
  4. DL-Norvaline

DL-Norvaline  (Synonyms: 2-Aminopentanoic acid)

Cat. No.: HY-W010510 Purity: ≥98.0%
SDS COA Handling Instructions

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DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.

For research use only. We do not sell to patients.

DL-Norvaline Chemical Structure

DL-Norvaline Chemical Structure

CAS No. : 760-78-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 33 In-stock
Solution
10 mM * 1 mL in Water USD 33 In-stock
Solid
100 mg USD 30 In-stock
500 mg USD 50 In-stock
5 g USD 60 In-stock
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50 g   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of DL-Norvaline:

DL-Norvaline Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

DL-Norvaline, a derivative of L-norvaline[1], L-norvaline is a non-competitive inhibitor of arginase[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DL-Norvaline Related Antibodies
Molecular Weight

117.15

Formula

C5H11NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCC(N)C(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (426.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.5361 mL 42.6803 mL 85.3606 mL
5 mM 1.7072 mL 8.5361 mL 17.0721 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 20 mg/mL (170.72 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (245 KB) HNMR (130 KB)

Handling Instructions (2659 KB)
References
Cell Assay

A murine macrophage cell line (RAW264.7) is used throughout the study, RAW264.7 cells are induced by A. actinomycetemcomitans-lipopolysaccharide, cells are incubated with various concentrations of L-norvaline or DL-norvaline (0.01, 0.1, 1, 10 mM) and 10 μg of A. actinomycetemcomitans-lipopolysaccharide. In other experiments, cells are incubated with antimurine CD14 or antimurine toll-like receptor 2 and 4 antibody at room temperature for 1 h, washed three times, and then stimulated with 10 μg of A. actinomycetemcomitans-lipopolysaccharide. All experiments are repeated three times, each consisting of triplicate cultures[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 8.5361 mL 42.6803 mL 85.3606 mL 213.4016 mL
5 mM 1.7072 mL 8.5361 mL 17.0721 mL 42.6803 mL
10 mM 0.8536 mL 4.2680 mL 8.5361 mL 21.3402 mL
15 mM 0.5691 mL 2.8454 mL 5.6907 mL 14.2268 mL
20 mM 0.4268 mL 2.1340 mL 4.2680 mL 10.6701 mL
25 mM 0.3414 mL 1.7072 mL 3.4144 mL 8.5361 mL
30 mM 0.2845 mL 1.4227 mL 2.8454 mL 7.1134 mL
40 mM 0.2134 mL 1.0670 mL 2.1340 mL 5.3350 mL
50 mM 0.1707 mL 0.8536 mL 1.7072 mL 4.2680 mL
60 mM 0.1423 mL 0.7113 mL 1.4227 mL 3.5567 mL
80 mM 0.1067 mL 0.5335 mL 1.0670 mL 2.6675 mL
100 mM 0.0854 mL 0.4268 mL 0.8536 mL 2.1340 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DL-Norvaline Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-Norvaline760-78-12-Aminopentanoic acidEndogenous MetaboliteArginaseInhibitorinhibitorinhibit

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