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  6. Metabolism/Protease Compound Library
Metabolism/Protease Compound Library

Cat. No.: HY-L012

Metabolism is the set of life-sustaining chemical reactions in organisms. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of natural product small molecules within a cell or tissue. Acting as catalysts, enzymes are crucial to metabolism - they allow a reaction to proceed more rapidly - and they also allow the regulation of the rate of a metabolic reaction. Proteases are used throughout an organism for various metabolic processes. Proteases control a great variety of physiological processes that are critical for life, including the immune response, cell cycle, cell death, wound healing, food digestion, and protein and organelle recycling. Imbalances in metabolic activities have been found to be critical in a number of pathologies, such as cardiovascular diseases, inflammation, cancer, and neurodegenerative diseases.

MCE designs a unique collection of 4,645 Metabolism/Protease-related small molecules that act as a useful tool for drug discovery of metabolism-related diseases.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Description & Advantages

•   A unique collection of 4,645 Metabolism/Protease-related small molecules for high throughput screening (HTS) and high content screening (HCS).

•   Targets such as PDE, Cytochrome P450, HMG-CoA Reductase, DPP4, Proteasome, HCV Protease, IDO, Cathepsin, MMP, etc.

•   A useful tool for drug discovery of metabolism-related diseases.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   More detailed compound information with structure, IC50, and brief introduction.

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

Product Details

Formulation:

A collection of 4,645 Metabolism/Protease related compounds supplied as pre-dissolved Solutions or Solid
Solution: 4,527 compounds supplied in 10 mM solution, 93 compounds supplied in 2 mM solution, 25 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

Composition

PPAR (119)

MMP (107)

HSP (87)

LXR (31)

FAAH (29)

ROR (28)

MAGL (26)

FXR (23)

NAMPT (19)

PAI-1 (19)

PCSK9 (12)

COMT (10)

SGK (10)

PDHK (9)

PDI (9)

FABP (7)

DGK (6)

UGT (6)

CETP (5)

SHMT (5)

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  •  Specific Compounds
  •  Quantities
  •  Plate Map
  •  Concentration
  •  Form (Solid or Solution)
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    Product Name:
    Metabolism/Protease Compound Library
    Cat. No.:
    HY-L012
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack

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