2. One-stop Drug Screening
  3. Screening Libraries
  4. Drug Fragment Library
Drug Fragment Library

Cat. No.: HY-L904

The MCE 1K Drug Fragment Library consists of 1,000 drug fragments. These drug fragments are derived from 2,946 FDA-approved drug molecules, and fragments from one drug can appear in other drugs, so these fragments are somewhat correlated with good PK/PD properties. Fragment-based screening can reserve enough chemical space for subsequent structural optimization. This compound library is an essential tool for drug screening based on FBDD (Fragment-Based Drug Discovery).

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, and 2 mM for compounds with solubility between 2 mM and 10 mM.

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  • 384-well Microplate with Peelable Foil Seal
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Compound Screening Libraries

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Description & Advantages

•    These fragments are derived from 2,946 FDA-approved drug molecules by BRICS and Recap algorithm and the simple fragment were removed.

•    More than 600 fragments compatible with “Rule of three”, with multiple characteristics such as the molecular weight <300, the number of hydrogen bond donors and acceptors ≤3, the number of rotatable bonds ≤ 3, and cLogP <3.

•    Provide a compound library based on fragment derivation and custom synthesis services, aiming to reduce your synthesis costs and shorten research and development time.

•   NMR and HPLC validated to ensure high purity and quality.

Product Details

•    These fragments are derived from 2,946 FDA-approved drug molecules by BRICS and Recap algorithm and the simple fragment were removed.

•    More than 600 fragments compatible with “Rule of three”, with multiple characteristics such as the molecular weight <300, the number of hydrogen bond donors and acceptors ≤3, the number of rotatable bonds ≤ 3, and cLogP <3.

•    Provide a compound library based on fragment derivation and custom synthesis services, aiming to reduce your synthesis costs and shorten research and development time.

•   NMR and HPLC validated to ensure high purity and quality.

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Compound Customization
  •  Specific Compounds
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  •  Plate Map
  •  Concentration
  •  Form (Solid or Solution)
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    Drug Fragment Library
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack

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