2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Antifolate Endogenous Metabolite
  4. Folinic acid calcium

Folinic acid calcium  (Synonyms: Leucovorin calcium; Calcium folinate)

Cat. No.: HY-13664 Purity: 99.71%
SDS COA Handling Instructions

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Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity.

For research use only. We do not sell to patients.

Folinic acid calcium Chemical Structure

Folinic acid calcium Chemical Structure

CAS No. : 1492-18-8

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500 mg USD 150 In-stock
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Customer Review

Based on 10 publication(s) in Google Scholar

Other Forms of Folinic acid calcium:

Folinic acid calcium Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Folinic acid calcium Related Antibodies
In Vivo

Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2]
Dosage: 7.0 mg/kg
Administration: Intraperitoneal injection; every second day; for 3 weeks
Result: Following methotrexate (MTX) administration appears to reverse this growth inhibition.
Clinical Trial
Molecular Weight

511.50

Formula

C20H21CaN7O7
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N[C@H](C([O-])=O)CCC([O-])=O)C(C=C1)=CC=C1NCC(N2C=O)CNC3=C2C(N=C(N)N3)=O.[Ca+2]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (97.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9550 mL 9.7752 mL 19.5503 mL
5 mM 0.3910 mL 1.9550 mL 3.9101 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.71%

SDS (393 KB)

COA (248 KB) LCMS (90 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.9550 mL 9.7752 mL 19.5503 mL 48.8759 mL
5 mM 0.3910 mL 1.9550 mL 3.9101 mL 9.7752 mL
10 mM 0.1955 mL 0.9775 mL 1.9550 mL 4.8876 mL
15 mM 0.1303 mL 0.6517 mL 1.3034 mL 3.2584 mL
20 mM 0.0978 mL 0.4888 mL 0.9775 mL 2.4438 mL
25 mM 0.0782 mL 0.3910 mL 0.7820 mL 1.9550 mL
30 mM 0.0652 mL 0.3258 mL 0.6517 mL 1.6292 mL
40 mM 0.0489 mL 0.2444 mL 0.4888 mL 1.2219 mL
50 mM 0.0391 mL 0.1955 mL 0.3910 mL 0.9775 mL
60 mM 0.0326 mL 0.1629 mL 0.3258 mL 0.8146 mL
80 mM 0.0244 mL 0.1222 mL 0.2444 mL 0.6109 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Folinic acid calcium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Folinic acid1492-18-8Leucovorin Calcium folinateAntifolateEndogenous MetaboliteInhibitorinhibitorinhibit

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