2. GPCR/G Protein
  3. GnRH Receptor
  4. Luteinizing Hormone Releasing Hormone (LH-RH), salmon

Luteinizing Hormone Releasing Hormone (LH-RH), salmon  (Synonyms: Salmon GnRH; Salmon gonadotropin-releasing hormone; sGnRH)

Cat. No.: HY-P0243 Purity: 99.69%
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Luteinizing Hormone Releasing Hormone (LH-RH), salmon (Salmon GnRH) is the hypophysiotropic decapeptide synthesized in the hypothalamus that plays a crucial role in the control of reproductive functions.

For research use only. We do not sell to patients.

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Luteinizing Hormone Releasing Hormone (LH-RH), salmon Chemical Structure

Luteinizing Hormone Releasing Hormone (LH-RH), salmon Chemical Structure

CAS No. : 86073-88-3

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1 mg USD 96 In-stock
5 mg USD 216 In-stock
10 mg USD 384 In-stock
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Based on 1 publication(s) in Google Scholar

Luteinizing Hormone Releasing Hormone (LH-RH), salmon Related Antibodies

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  • Purity & Documentation

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Description

Luteinizing Hormone Releasing Hormone (LH-RH), salmon (Salmon GnRH) is the hypophysiotropic decapeptide synthesized in the hypothalamus that plays a crucial role in the control of reproductive functions.

In Vitro

Luteinizing hormone-releasing hormone (LHRH) is the key hormone in the control of reproductive functions.LHRH acts as an antimitogenic factor through the activation of the Gi-cAMP intracellular signaling pathway. LHRH might act as an inhibitory factor on both cell proliferation and metastatic behavior in melanoma cells[1]. The hypothalamic decapeptide luteinizing hormone-releasing hormone (LHRH) plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn promote gonadal functions and regulate sex steroid secretion. The effects of LHRH are mediated by high-affinity G protein-coupled LHRH-receptor (LHRH-R) on pituitary gonadotropes. The responses to LHRH vary under different conditions and critically depend on the regimens of administration and doses delivered to gonadotrope cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Luteinizing Hormone Releasing Hormone (LH-RH), salmon Related Antibodies
Molecular Weight

1212.31

Formula

C60H73N15O13
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{Glp}-His-Trp-Ser-Tyr-Gly-Trp-Leu-Pro-Gly-NH2
Sequence Shortening

{Glp}-HWSYGWLPG-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
Purity & Documentation
References
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Luteinizing Hormone Releasing Hormone (LH-RH), salmon Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Luteinizing Hormone Releasing Hormone (LH-RH), salmon86073-88-3Salmon GnRH Salmon gonadotropin-releasing hormone sGnRHGnRH ReceptorGonadotropin releasing hormone receptorGNRHRInhibitorinhibitorinhibit

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Luteinizing Hormone Releasing Hormone (LH-RH), salmon
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