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  4. NE 10790

NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.

For research use only. We do not sell to patients.

NE 10790 Chemical Structure

NE 10790 Chemical Structure

CAS No. : 152831-36-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 77 In-stock
Solution
10 mM * 1 mL in Water USD 77 In-stock
Solid
5 mg USD 70 In-stock
10 mg USD 130 In-stock
25 mg USD 310 In-stock
50 mg USD 527 In-stock
100 mg USD 895 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

NE 10790 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE NE 10790

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.

IC50 & Target

FPP synthase[1].
Cellular Effect
Cell Line Type Value Description References
J774 IC50
2800 μM
Compound: (+/-)-1
Cytotoxicity against mouse J774 cells assessed as cell viability after 48 hrs by alamar blue assay
Cytotoxicity against mouse J774 cells assessed as cell viability after 48 hrs by alamar blue assay
[PMID: 20394422]
Osteoclast IC50
970 μM
Compound: (+/-)-1
Antiresorptive activity in rabbit osteoclasts assessed as number of actin rings after 48 hrs using TRITC-phelloidin stain relative to control
Antiresorptive activity in rabbit osteoclasts assessed as number of actin rings after 48 hrs using TRITC-phelloidin stain relative to control
[PMID: 20394422]
In Vitro

NE 10790 inhibits incorporation of [14C]mevalonic acid into Rab6, but not into H-Ras or Rap1, proteins that are modified by FTase and GGTase I, respectively. NE 10790 reduces viability in J774 cells. NE 10790 prevents prenylation of 22-26-kDa proteins that are not modified by FTase or GGTase I[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NE 10790 Related Antibodies
Molecular Weight

247.14

Formula

C8H10NO6P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C(O)=O)(P(O)(O)=O)CC1=CC=CN=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

0.1 M NaOH : 20 mg/mL (80.93 mM; ultrasonic and adjust pH to 6 with NaOH)

H2O : 5 mg/mL (20.23 mM; ultrasonic and adjust pH to 6 with NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0463 mL 20.2314 mL 40.4629 mL
5 mM 0.8093 mL 4.0463 mL 8.0926 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 2 mg/mL (8.09 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.50%

SDS (252 KB)

COA (257 KB) HNMR (102 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / 0.1 M NaOH 1 mM 4.0463 mL 20.2314 mL 40.4629 mL 101.1572 mL
5 mM 0.8093 mL 4.0463 mL 8.0926 mL 20.2314 mL
10 mM 0.4046 mL 2.0231 mL 4.0463 mL 10.1157 mL
15 mM 0.2698 mL 1.3488 mL 2.6975 mL 6.7438 mL
20 mM 0.2023 mL 1.0116 mL 2.0231 mL 5.0579 mL
0.1 M NaOH 25 mM 0.1619 mL 0.8093 mL 1.6185 mL 4.0463 mL
30 mM 0.1349 mL 0.6744 mL 1.3488 mL 3.3719 mL
40 mM 0.1012 mL 0.5058 mL 1.0116 mL 2.5289 mL
50 mM 0.0809 mL 0.4046 mL 0.8093 mL 2.0231 mL
60 mM 0.0674 mL 0.3372 mL 0.6744 mL 1.6860 mL
80 mM 0.0506 mL 0.2529 mL 0.5058 mL 1.2645 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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NE 10790 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NE 10790152831-36-23-PEHPCNE10790NE-10790OthersInhibitorinhibitorinhibit

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