Smallanthus uvedalia (Linnaeus) Mackenzie

Smallanthus uvedalia (Linnaeus) Mackenzie (3):

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

Coleon-U-quinone	65714-83-2
Coleon-U-quinone is a potent P-gp inhibitor. Coleon-U-quinone can inhibit cancer cells viability and sensitize multidrug resistance cancer cells to Doxorubicin (HY-15142A).

8α,9α-Epoxycoleon-U-quinone	93800-59-0
8α,9α-Epoxycoleon-U-quinone (compound 3) is a p-glycoprotein (P-gp) regulator that is selective for cancer cells (SI=2.0). 8α,9α-Epoxycoleon-U-quinone effectively inhibits P-gp activity in NCI-H460/R cells. 8α,9α-Epoxycoleon-U-quinone also reverses the resistance of cancer cells to Doxorubicin (DOX) (HY-15142A) and enhances the anticancer effect of DOX.

Uvedalin	24694-79-9
Uvedalin is a conjugated γ-lactone and oxygenated germacranolide that can be isolated from Polymnia uvedalia (L.).

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