2. Signaling Pathways
  3. Claudin

Claudin

Claudins are a family of transmembrane proteins, are the most important components of the tight junctions (zonulae occludentes). They have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm. Claudin expression and functions are regulated at multiple levels and by diverse mechanisms. Delocalization of claudins from membrane appears to be common among the transformed cells. Constitutive activation of Ras or Ras-mediated signaling pathway/s is one of the initial steps during tumorigenesis that is causatively associated with neoplastic transformation. Importantly, claudins are expressed in the epithelial cells and in a tissue-specific manner and changes among claudin family members in cancer follow tissue-specific and sometimes contrasting pattern. Thus, claudin family of proteins may hold the potential cue to the heterogeneity among the tumors of epithelial origin and beyond being useful markers may also help provide therapeutic opportunities suited for specific cancer type[1].

Claudin Related Products (6):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W014507
    9,10-Phenanthrenequinone
    		Inhibitor 99.95%
    9,10-Phenanthrenequinone is an inhibitor of claudin-5/CLDN5 that induces apoptosis via a NO synthase/ROS-dependent mechanism. 9,10-Phenanthrenequinone also promotes endothelial barrier dysfunction by promoting caspase activation and DNA fragmentation, and reducing CLDN5 expression and proteasomal proteolysis.
    9,10-Phenanthrenequinone
  • HY-171152
    NSC 357754
    		Inhibitor
    NSC 357754 is an inhibitor of Claudin. NSC 357754 can increase the transepithelial electrical resistance of cells and reduce the permeability of specific cations. NSC 357754 can be used in the research of intestinal diseases mediated by Claudin-2 and/or Claudin-15.
    NSC 357754
  • HY-P991200
    OM-7D3-B3
    		Inhibitor
    OM-7D3-B3 is a monoclonal antibody targeting human claudin-1 (CLDN1) (Kd = 4 nM). OM-7D3-B3 blocks the process in which CLDN1 is involved in the entry of hepatitis C virus (HCV) into cells. OM-7D3-B3 is promising for research of HCV infection.
    OM-7D3-B3
  • HY-P991140
    Garetatug
    		Ligand
    Garetatug is a humanized monoclonal antibody targeting human CLDN18 (claudin-18). Garetatug specifically binds to CLDN18, interfering with relevant cell signaling pathways and exerting antitumor activity.
    Garetatug
  • HY-P991143
    Ixotatug
    		Ligand
    Ixotatug is a monoclonal antibody targeting human CLDN6 (claudin-6). Ixotatug specifically binds to CLDN6, interfering with relevant signaling pathways in tumor cells and exerting antitumor activity. Ixotatug is promising for research of cancers.
    Ixotatug
  • HY-P991163
    Tixentamig
    		Inhibitor
    Tixentamig is a bispecific monoclonal antibody targeting human CD3 ε and CLDN18 (claudin 18). Tixentamig is promising for research of cancers.
    Tixentamig