Nucleocidin (Synonyms: 4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007)

Cat. No.: HY-100496: FAQs
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Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.

For research use only. We do not sell to patients.

Nucleocidin Chemical Structure

CAS No. : 24751-69-7

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Description	Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.
IC₅₀ & Target	Antibacterial^[1].
In Vitro	Although appreciable inhibition occurrs at low concentrations of nucleocidin, it is not possible to obtain complete inhibition even at 10^-3 M. An appreciable lag occurrs before any inhibition by nucleocidin is detectable, and the length of this lag period varies inversely with the concentration of nucleocidin. Similar results are obtained when nucleocidin is added to the cell-free system from reticulocytes. By contrast, essentially complete inhibition is obtained at 10^-3 M puromycin, and only at the lowest concentrations is any lag detectable. It seems that nucleocidin exhibits the pattern typical of many antibiotics, i.e. it inhibits incorporation at a stage subsequent to the formation of aminoacyl-S-RNA^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Nucleocidin Related Antibodies
Molecular Weight	364.31
Formula	C₁₀H₁₃FN₆O₆S
CAS No.	24751-69-7
SMILES	O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@@]3(F)COS(=O)(N)=O
Structure Classification	Antibiotics Disease Research Anti-parasitic Antibiotics Other Antibiotics
Initial Source	Microorganisms Streptomyces calvus
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (272 KB) Handling Instructions (2659 KB)
References	[1]. Florini JR, et al. Inhibition of protein synthesis in vitro and in vivo by nucleocidin, an antitrypanosomal antibiotic. J Biol Chem. 1966 Mar 10;241(5):1091-8. [Content Brief]

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nucleocidin24751-69-74'-Fluoro-5'-O-sulfamoyladenosine NSC 521007NSC521007NSC 521007NSC-521007BacterialInhibitorinhibitorinhibit

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Nucleocidin (Synonyms: 4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007)

Nucleocidin Related Antibodies

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