2. PROTAC
  3. Ligands for Target Protein for PROTAC
  4. SirReal1-O-propargyl

SirReal1-O-propargyl  (Synonyms: PROTAC Sirt2-binding moiety 1)

Cat. No.: HY-107453
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SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2. SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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SirReal1-O-propargyl Chemical Structure

SirReal1-O-propargyl Chemical Structure

CAS No. : 1862237-99-7

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SirReal1-O-propargyl Related Antibodies

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Description

SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2[1]. SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

IC50: 2.4 μM (Sirt2)[1].
Molecular Weight

424.54

Formula

C21H20N4O2S2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(NC1=NC=C(CC2=CC=CC(OCC#C)=C2)S1)CSC3=NC(C)=CC(C)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation
References
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SirReal1-O-propargyl Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SirReal1-O-propargyl1862237-99-7PROTAC Sirt2-binding moiety 1Ligands for Target Protein for PROTACTarget Protein-binding MoietyInhibitorinhibitorinhibit

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