Riboflavin Tetrabutyrate

Name: Riboflavin Tetrabutyrate
Brand: MedChemExpress
SKU: HY-B2239
Rating: 4.5 (1 reviews)

Cat. No.: HY-B2239 Purity: 98.93%: FAQs
Data Sheet SDS COA Handling Instructions

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Riboflavin Tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.

For research use only. We do not sell to patients.

Riboflavin Tetrabutyrate Chemical Structure

CAS No. : 752-56-7

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 66	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description

Riboflavin Tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.

In Vitro

Riboflavin Tetrabutyrate inhibits oxygen uptake by lipid peroxidation. Riboflavin Tetrabutyrate is suppressive against both NADPH-coupled and ascorbate-induced microsomal lipid peroxidation. Riboflavin Tetrabutyrate seems to exhibit its antioxidative action at or after the hydrogen atom is abstracted as a free radical from an active methylene group of polyunsaturated fatty acids during the process of enzymic oxidation-reduction reaction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Riboflavin Tetrabutyrate might improve the metabolism of lipids in patients suffering from atherosclerosis, diabetes, fatty liver and so on through the inhibition of lipid peroxide, resulting in the decrease of the elevated serum lipid^[1]. Feeding of Riboflavin Tetrabutyrate results in an increase in the hepatic activity of 3-ketoacyl-CoA thiolase by 50% of the control level, while the activities of renal 3-ketoacyl-CoA thiolase and of hepatic and renal acyl-CoA synthetase and acyl-CoA dehydrogenase remain unaffected. The increase in hepatic 3-ketoacyl-CoA thiolase activity suggests that prolonged Riboflavin Tetrabutyrate administration results in an increased beta-oxidation of fatty acid in the liver ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

656.72

Formula

C₃₃H₄₄N₄O₁₀

CAS No.

752-56-7

Appearance

Solid

Color

Yellow to orange

SMILES

O=C(CCC)O[C@H]([C@H](OC(CCC)=O)[C@H](OC(CCC)=O)COC(CCC)=O)CN1C(C=C(C)C(C)=C2)=C2N=C(C(N3)=O)C1=NC3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (152.27 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5227 mL	7.6136 mL	15.2272 mL
5 mM	0.3045 mL	1.5227 mL	3.0454 mL
10 mM	0.1523 mL	0.7614 mL	1.5227 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.93%

Select Batch:

Data Sheet (281 KB) SDS (393 KB)

COA (259 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Tahara K, et al. Effect of riboflavin and riboflavin 2',3',4',5'-tetrabutyrate on rat liver microsomallipid peroxidation. J Nutr Sci Vitaminol (Tokyo). 1974;20(2):81-8. [Content Brief]

[2]. Okuno E, et al. Effect of chronic administration of riboflavin 2',3',4',5'-tetrabutyrate on the hepatic enzymes of fatty acid oxidation in the rat. J Nutr Sci Vitaminol (Tokyo). 1983 Dec;29(6):637-42. [Content Brief]

[3]. Yagi K, et al. Studies on fatty acid esters of flavins. VI. Incorporation of riboflavin part of riboflavin tetrabutyrate-2-14C into flavin nucleotides in the organs of rat. J Vitaminol (Kyoto). 1969 Jun 10;15(2):155-9. [Content Brief]

Animal Administration
^[3]

Rats: Riboflavin tetrabutyrate-¹⁴C (700 μg, corresponding to 400 μg of riboflavin; total radioactivity 2.19×10⁵ cpm) is suspended in 0.2mL of soybean oil and given per os . In the case of injection, same amount of Riboflavin tetrabutyrate-¹⁴C is dissolved in 1mL of soybean oil and injected subcutaneously into the back of rat^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Tahara K, et al. Effect of riboflavin and riboflavin 2',3',4',5'-tetrabutyrate on rat liver microsomallipid peroxidation. J Nutr Sci Vitaminol (Tokyo). 1974;20(2):81-8. [Content Brief]

[2]. Okuno E, et al. Effect of chronic administration of riboflavin 2',3',4',5'-tetrabutyrate on the hepatic enzymes of fatty acid oxidation in the rat. J Nutr Sci Vitaminol (Tokyo). 1983 Dec;29(6):637-42. [Content Brief]

[3]. Yagi K, et al. Studies on fatty acid esters of flavins. VI. Incorporation of riboflavin part of riboflavin tetrabutyrate-2-14C into flavin nucleotides in the organs of rat. J Vitaminol (Kyoto). 1969 Jun 10;15(2):155-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5227 mL	7.6136 mL	15.2272 mL	38.0680 mL
	5 mM	0.3045 mL	1.5227 mL	3.0454 mL	7.6136 mL
	10 mM	0.1523 mL	0.7614 mL	1.5227 mL	3.8068 mL
	15 mM	0.1015 mL	0.5076 mL	1.0151 mL	2.5379 mL
	20 mM	0.0761 mL	0.3807 mL	0.7614 mL	1.9034 mL
	25 mM	0.0609 mL	0.3045 mL	0.6091 mL	1.5227 mL
	30 mM	0.0508 mL	0.2538 mL	0.5076 mL	1.2689 mL
	40 mM	0.0381 mL	0.1903 mL	0.3807 mL	0.9517 mL
	50 mM	0.0305 mL	0.1523 mL	0.3045 mL	0.7614 mL
	60 mM	0.0254 mL	0.1269 mL	0.2538 mL	0.6345 mL
	80 mM	0.0190 mL	0.0952 mL	0.1903 mL	0.4758 mL
	100 mM	0.0152 mL	0.0761 mL	0.1523 mL	0.3807 mL