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  6. Oxygen Sensing Compound Library
Oxygen Sensing Compound Library

Cat. No.: HY-L045

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.

HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O2 concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.

MCE offers a unique collection of 2,656 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Description & Advantages

•   A unique collection of 2,656 oxygen sensing related compounds for high throughput screening (HTS) and high content screening (HCS).

•   Targets such as HIF, HIF Prolyl-Hydroxylase, E1/E2/E3 Enzyme, ROS, PI3K, MAPK, etc.

•   Bioactivity and safety confirmed by preclinical research and clinical trials, some compounds have been approved by FDA.

•   A useful tool to study hypoxia, oxidative stress.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   NMR and HPLC validated ensure high purity.

•   All compounds are in stock and continuously updated.

Product Details

Formulation:

A collection of 2,656 oxygen sensing compounds supplied as pre-dissolved Solutions or Solid
Solution: 2,597 compounds supplied in 10 mM solution, 47 compounds supplied in 2 mM solution, 12 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

Composition

NF-κB (303)

PI3K (197)

Akt (144)

HDAC (132)

ERK (113)

mTOR (105)

Ras (97)

PKC (83)

AMPK (81)

GSK-3 (73)

JNK (56)

Raf (56)

MEK (50)

COX (45)

HIV (42)

CDK (38)

PPAR (30)

STAT (27)

MAP3K (24)

VEGFR (22)

MMP (19)

EGFR (17)

PARP (17)

JAK (16)

PDK-1 (16)

Wnt (16)

PI4K (15)

MAP4K (14)

ROCK (14)

PKA (13)

Src (12)

HBV (11)

IKK (11)

FLT3 (10)

HSP (10)

HSV (10)

FAK (9)

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    Cat. No.:
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack

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