2. Autophagy
  3. Mitophagy
  4. Sulfosuccinimidyl oleate

Sulfosuccinimidyl oleate  (Synonyms: Sulfo-N-succinimidyl oleate)

Cat. No.: HY-112847
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Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect.

For research use only. We do not sell to patients.

Sulfosuccinimidyl oleate Chemical Structure

Sulfosuccinimidyl oleate Chemical Structure

CAS No. : 135661-44-8

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Based on 21 publication(s) in Google Scholar

Other Forms of Sulfosuccinimidyl oleate:

Sulfosuccinimidyl oleate Related Antibodies

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Description

Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1][2].

In Vitro

Sulfosuccinimidyl oleate (20 μM and 50 μM, 24 hours) alone does not alter the cellular viability. Exposure to 100 ng/ml LPS+5 ng/mL IFNγ modestly, yet significantly reduces the viability of the BV2 cells. Co-treatment with Sulfosuccinimidyl oleate prevents the LPS+IFNγ-induced reduction in the cell viability[1].
Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfosuccinimidyl oleate Related Antibodies

Cell Viability Assay[1]

Cell Line: BV2 cells
Concentration: 20 μM and 50 μM
Incubation Time: 24 hours
Result: Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100 ng/mL LPS and 5 ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it.

Western Blot Analysis[1]

Cell Line: BV2 cells
Concentration: 50 μM
Incubation Time: 24 hours
Result: Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38.
In Vivo

Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls in male BALB/cABom mice with pMCAo model. In addition, Sulfosuccinimidyl oleate at 50 mg/kg is suitable to see a beneficial effect after stroke[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-month-old male BALB/cABom mice with pMCAo model[1]
Dosage: 50 mg/kg
Administration: Administered once by single oral gavage
Result: Reduced brain damage following ischemia. Attenuated infarct size.
Molecular Weight

459.60

Formula

C22H37NO7S
CAS No.
SMILES

O=S(C(C1)C(N(OC(CCCCCCC/C=C\CCCCCCCC)=O)C1=O)=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sulfosuccinimidyl oleate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfosuccinimidyl oleate135661-44-8Sulfo-N-succinimidyl oleateMitophagyMitochondrial AutophagyInhibitorinhibitorinhibit

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