2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. Synaptamide

Synaptamide  (Synonyms: N-Docosahexaenoyl ethanolamine (DHEA); Docosahexaenoyl ethanolamide)

Cat. No.: HY-100197 Purity: 99.30%
COA Handling Instructions

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Synaptamide (Dehydroepiandrosteron; DHEA) is an endogenous metabolite and structural analogue of Anandamide. Synaptamide binds to both the cannabinoid-1 and 2 (CB1 and CB2) cannabinoid receptors and has anti-inflammatory properties. Synaptamide is the first small-molecule endogenous ligand of an adhesion G protein-coupled receptor (aGPCR) .

For research use only. We do not sell to patients.

Synaptamide Chemical Structure

Synaptamide Chemical Structure

CAS No. : 162758-94-3

Size Price Stock Quantity
Solvent
5 mg (67 mM * 200 μL in Ethanol) USD 72 In-stock
Solvent
10 mg (67 mM * 400 μL in Ethanol) USD 114 In-stock
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Based on 1 publication(s) in Google Scholar

Synaptamide Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Synaptamide

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CB1 CB2

  • Biological Activity

  • Purity & Documentation

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Description

Synaptamide (Dehydroepiandrosteron; DHEA) is an endogenous metabolite and structural analogue of Anandamide. Synaptamide binds to both the cannabinoid-1 and 2 (CB1 and CB2) cannabinoid receptors and has anti-inflammatory properties. Synaptamide is the first small-molecule endogenous ligand of an adhesion G protein-coupled receptor (aGPCR)[1] [2][3].

IC50 & Target[2]

CB1

633 nM (Ki)

CB2

3843 nM (Ki)

In Vitro

Synaptamide (Dehydroepiandrosteron; DHEA) is a weak agonist at both CB1 and CB2 receptors[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Synaptamide Related Antibodies
In Vivo

Synaptamide (10 mg/kg; subcutaneously; daily for 7 days) promotes cognitive recovery in rats subjected to mild traumatic brain injury (mTBI)[1].
Synaptamide (2-10 mg/kg; adult male C57BL/6J mice) reduced the levels of nociceptive and inflammatory pain-related behaviour over 60 min in the intraplantar formaldehyde assay via both intraperitoneal and local intraplantar administration[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats;260 ± 20 g, age 3 months; mTBI model)[1]
Dosage: 10 mg/kg
Administration: Subcutaneously; daily for 7 days
Result: Reversed the mTBI-induced cognitive deficits.
Molecular Weight

371.56

Formula

C24H37NO2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(NCCO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Solvent & Solubility
In Vitro: 

Ethanol : 25 mg/mL (67.28 mM; Need ultrasonic)

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 10 mg/mL (26.91 mM); Clear solution

    This protocol yields a clear solution of ≥ 10 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (100.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% EtOH    90% Corn Oil

    Solubility: ≥ 10 mg/mL (26.91 mM); Clear solution

    This protocol yields a clear solution of ≥ 10 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (100.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.30%

COA (237 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.6914 mL 13.4568 mL 26.9136 mL 67.2839 mL
5 mM 0.5383 mL 2.6914 mL 5.3827 mL 13.4568 mL
10 mM 0.2691 mL 1.3457 mL 2.6914 mL 6.7284 mL
15 mM 0.1794 mL 0.8971 mL 1.7942 mL 4.4856 mL
20 mM 0.1346 mL 0.6728 mL 1.3457 mL 3.3642 mL
25 mM 0.1077 mL 0.5383 mL 1.0765 mL 2.6914 mL
30 mM 0.0897 mL 0.4486 mL 0.8971 mL 2.2428 mL
40 mM 0.0673 mL 0.3364 mL 0.6728 mL 1.6821 mL
50 mM 0.0538 mL 0.2691 mL 0.5383 mL 1.3457 mL
60 mM 0.0449 mL 0.2243 mL 0.4486 mL 1.1214 mL
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Synaptamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Synaptamide162758-94-3N-Docosahexaenoyl ethanolamine (DHEA) Docosahexaenoyl ethanolamideCannabinoid ReceptorendogenousligandinflammatorynociceptiveInhibitorinhibitorinhibit

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