2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Antifolate
  5. Antifolate Inhibitor

Antifolate Inhibitor

Antifolate Inhibitors (12):

Cat. No. Product Name Effect Purity
  • HY-10820BR
    Pemetrexed disodium heptahydrate (Standard)
    		Inhibitor
    Pemetrexed (disodium heptahydrate) (Standard) is the analytical standard of Pemetrexed (disodium heptahydrate). This product is intended for research and analytical applications. Pemetrexed disodium heptahydrate is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.
  • HY-10820B
    Pemetrexed disodium heptahydrate
    		Inhibitor 99.97%
    Pemetrexed disodium heptahydrate is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.
  • HY-107033
    Tetroxoprim
    		Inhibitor 99.32%
    Tetroxoprim is an antimicrobial DHFR inhibitor.
  • HY-W003561
    DHFR-IN-3
    		Inhibitor 99.64%
    DHFR-IN-3 is a dihydrofolate reductase (DHFR) inhibitor with the IC50 values of 19 μM and 12 μM in rat liver and P. carinii DHFR, respectively.
  • HY-157217
    Antitumor agent-99
    		Inhibitor
    Antitumor agent-99 (compound 7) is an anticancer agent targeting FRα/β and PCFT. Antitumor agent-99 inhibits R2/PCFT4 (PCFT), RT16(FRα), and D4(FRβ) cells with IC50s of 51.46 nM, 2.53 nM, and 2.98 nM, respectively.
  • HY-147661
    DHFR-IN-2
    		Inhibitor
    DHFR-IN-2 (compound 4e) is a potent and uncompetitive inhibitor for MtDHFR (dihydrofolate reductase from M. tuberculosis), with an IC50 of 7 μM. DHFR-IN-2 can be used for tuberculosis (TB) research.
  • HY-121207
    Denopterin
    		Inhibitor
    Denopterin is a dihydrofolate reductase (DHFR) inhibitor and an antifolate agent. Denopterin is an antimetabolite that has toxic effects on cells and can be used for cancer.
  • HY-124350R
    10-Formylfolic acid (Standard)
    		Inhibitor
    10-Formylfolic acid (Standard) is the analytical standard of 10-Formylfolic acid. This product is intended for research and analytical applications. 10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia.
  • HY-124350
    10-Formylfolic acid
    		Inhibitor
    10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia.
  • HY-122259
    AMPte-Glu-γ-Glu
    		Inhibitor
    AMPte-Glu-γ-Glu is a substrate for folylpoly-γ-glutamate synthetase (FPGS). AMPte-Glu-γ-Glu exhibits cytotoxicity against chinese hamster ovaries cells, with IC50s of 20, 350 and 3 nM, for Pro3, R2, and 43-10, respectively.
  • HY-107033R
    Tetroxoprim (Standard)
    		Inhibitor
    Tetroxoprim (Standard) is the analytical standard of Tetroxoprim. This product is intended for research and analytical applications. Tetroxoprim is an antimicrobial DHFR inhibitor.
  • HY-123751
    Antifolate C1
    		Inhibitor
    Antifolate C1 (AGF 94) is a GARFTase inhibitor. Antifolate C1 inhibits de novo purine biosynthesis. Antifolate C1 inhibits cell proliferation.