2. Signaling Pathways
  3. Immunology/Inflammation
  4. CD6

CD6

Cluster of Differentiation 6

CD6 (Cluster of Differentiation 6) is a surface glycoprotein of T cells and a subset of B cells, and belongs to the superfamily of scavenger receptor cysteine-rich (SRCR) glycoproteins. CD166, ALCAM and CD318 are ligands for CD6. CD6 interacts with its ligands and plays a key role in thymocyte development, T cell activation and immune responses. CD6 is structurally similar to CD5. CD6 and CD5 have been regarded as co-stimulatory receptors that amplify T-cell receptor (TCR)-dependent activation. CD6 is an important target for therapy against autoimmune diseases, such as Anti-CD6 monoclonal antibody (mAb)[1][2].

CD6 Related Products (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P99252
    Itolizumab
    Itolizumab (Anti-Human CD6 Recombinant Antibody) is a humanized recombinant anti-CD6 monoclonal antibody (MAb) targeting the extracellular SRCR distal domain 1 of CD6. Itolizumab reduces T-cell proliferation and inhibits the production of pro-inflammatory cytokines, such as INF-γ, TNFα and IL-6. Itolizumab can be used in the research of psoriasis, rheumatoid arthritis (RA), COVID-19.
    Itolizumab