2. Signaling Pathways
  3. GPCR/G Protein
  4. CRFR
  5. CRFR Isoform
  6. CRFR Antagonist

CRFR Antagonist

CRFR Antagonists (23):

Cat. No. Product Name Effect Purity
  • HY-105332
    CRA1000
    		Antagonist
    CRA1000 is an orally active, selective and competitive CRF1 receptor antagonist with anxiolytic- and antidepressant-like properties.
  • HY-103375
    SN003
    		Antagonist
    SN003 is a reversible antagonist of corticotropin releasing factor receptor 1 (CRFR 1) (IC50 = 241 nM) that displays more than 1000-fold selectivity over CRFR 2. SN003 suppresses CRF-induced ACTH release in vitro. SN003 attenuates depressive-like behavior in rat.
  • HY-118821
    JTC-017
    		Antagonist
    JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats.