2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. CRISPR/Cas9
  5. CRISPR/Cas9 Inhibitor

CRISPR/Cas9 Inhibitor

CRISPR/Cas9 Inhibitors (5):

Cat. No. Product Name Effect Purity
  • HY-136251
    BRD0539
    		Inhibitor 98.03%
    BRD0539 is a cell-permeable and non-toxic inhibitor of CRISPR-Cas9. BRD0539 inhibits Streptococcus pyogenes Cas9 (SpCas9) (apparent IC50=22 μM) in an in vitro DNA cleavage assay.
  • HY-148730
    BRD7586
    		Inhibitor 99.03%
    BRD7586 is a cell-permeable small-molecule inhibitor of SpCas9. BRD7586 is the smallest known anti-CRISPR.
  • HY-145692
    Cas9-IN-3
    		Inhibitor
    Cas9-IN-3 is a potent Cas9 inhibitor (IC50=28 μM). CRISPR/Cas systems have revolutionized gene editing in various species.
  • HY-144118
    Cas9-IN-1
    		Inhibitor
    Cas9-IN-1 is a potent Cas9 inhibitor (IC50=7.02 μM), acting by binding to apo-Cas9 to prevent Cas9:gRNA complex formation.
  • HY-144119
    Cas9-IN-2
    		Inhibitor
    Cas9-IN-2 is a potent Cas9 inhibitor (IC50=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex formation, which can potentially be applied to modulate and control Cas9 activity in various applications.