2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Deubiquitinase
  5. USP7 Isoform
  6. USP7 Degrader

USP7 Degrader

USP7 Degraders (2):

Cat. No. Product Name Effect Purity
  • HY-175358
    PROTAC USP7 Degrader-1
    		Degrader
    PROTAC USP7 Degrader-1 (Compound 40) is a ubiquitin-specific protease 7 (USP7) PROTAC degrader with a DC50 of 25 nM. PROTAC USP7 Degrader-1 can be used for cancers like acute myeloid leukemia (AML) research. Pink: USP7 ligand (HY-175359); Blue: VHL ligase ligand (HY-112078); Black: linker
  • HY-159175
    XM-U-14
    		Degrader
    XM-U-14 is a selective PROTAC USP7 Degrader (DC50: 0.74 nM in inducing USP7 degradation in RS4;11 cell line). XM-U-14 upregulates the levels of p53 and p21. XM-U-14 also significantly inhibits acute lymphoblastic leukemia (ALL) cell growth (IC50: 0.5 nM and 8.3 nM for RS4;11 cells and Reh cells respectively). XM-U-14 induces apoptosis and cycle arrest. XM-U-14 inhibits tumor growth. (Blue: VHL ligand (HY-159465), Black: linker (HY-W539783); Pink: USP7 inhibitor (HY-159464)).