2. Signaling Pathways
  3. GPCR/G Protein
  4. Free Fatty Acid Receptor
  5. Free Fatty Acid Receptor Antagonist

Free Fatty Acid Receptor Antagonist

Free Fatty Acid Receptor Antagonists (3):

Cat. No. Product Name Effect Purity
  • HY-50691
    GW-1100
    		Antagonist
    GW-1100 is a selective GPR40 antagonist with a pIC50 of 6.9.
  • HY-19996
    AH-7614
    		Antagonist 99.73%
    AH-7614 is a potent and selective FFA4 (GPR120) antagonist, with pIC50s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. AH-7614 has selectivity for FFA4 over FFA1 (pIC50<4.6). AH-7614 is able to block effects of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist.
  • HY-101906
    DC260126
    		Antagonist 99.74%
    DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58 μM, respectively). DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis.