2. Signaling Pathways
  3. Cytoskeleton
  4. Integrin
  5. αvβ6 Isoform
  6. αvβ6 Inhibitor

αvβ6 Inhibitor

αvβ6 Inhibitors (5):

Cat. No. Product Name Effect Purity
  • HY-137561
    Bexotegrast
    		Inhibitor 98.94%
    Bexotegrast (PLN-74809) is an orally active, potent dual αvβ6/αvβ1 integrin inhibitor with Kd of 5.7 nM and 3.4 nM, respectively. Bexotegrast inhibits αvβ6- and αvβ1-induced TGF-β activation with IC50 values of 29.8 nM and 19.2 nM, respectively. Bexotegrast has antifibrogenic effects and block multiple avenues of TGF-β activation in the fibrotic lung.
  • HY-101473
    EMD527040
    		Inhibitor 99.94%
    EMD527040 is a potent and highly selective αvβ6 antagonist with antifibrotic activities. EMD527040 can be used for carcinoma and liver fibrosis research.
  • HY-168522
    αvβ6-IN-2
    		Inhibitor
    αvβ6-IN-2 (compound 20) is a potent and orally active αvβ6 integrin inhibitor with a pIC50 value of 7.8. αvβ6-IN-2 has the potential for the research of idiopathic pulmonary fibrosis.
  • HY-168521
    αvβ6-IN-1
    		Inhibitor
    αvβ6-IN-1 (compound 28) is a potent and orally active αvβ6 integrin inhibitor with a pIC50 value of 8.1. αvβ6-IN-1 has the potential for the research of idiopathic pulmonary fibrosis.
  • HY-153807
    αvβ6 integrin inhibitor 2
    		Inhibitor
    αvβ6 integrin inhibitor 2 is a potent ανβ6 integrin inhibitor with an IC50 of 96.5 nM (WO2020081154A1, example 19).