2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP
  5. MMP Inhibitor

MMP Inhibitor

MMP Isoform Comparison

MMP Inhibitors (338):

Cat. No. Product Name Effect Purity
  • HY-123438
    WAY-151693
    		Inhibitor
    WAY-151693, sulfonamide derivative of a hydroxamic acid, acts as a potent inhibitor of MMP13 in virtual screening.
  • HY-119110
    LY52
    		Inhibitor
    LY52 is an MMP-2 and MMP-9 inhibitor. LY52 can significantly block the proteolytic activity of gelatinases, reducing the expression of MMP-2 and MMP-9 in SKOV3 cells, thereby inhibiting cell invasion. LY52 can also suppress the pulmonary metastasis of Lewis lung carcinoma cells in mice. LY52 may be used in cancer research.
  • HY-B0689S1
    Indinavir-13C4,15N
    		Inhibitor
    Indinavir-13C4,15N (MK-639 (free base)-13C4,15N) is 13C and 15N labeled Indinavir. Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CLpro inhibitor.
  • HY-121514
    Talopeptin
    		Inhibitor
    Talopeptin is a metal protease inhibitor that can be produced by the streptomyces MK-23.
  • HY-B0099R
    Edaravone (Standard)
    		Inhibitor
    Edaravone (Standard) is the analytical standard of Edaravone. This product is intended for research and analytical applications. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.
  • HY-N0774R
    Isofraxidin (Standard)
    		Inhibitor
    Isofraxidin (Standard) is the analytical standard of Isofraxidin. This product is intended for research and analytical applications. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation.
  • HY-W004546R
    Abametapir (Standard)
    		Inhibitor
    Abametapir (Standard) is the analytical standard of Abametapir. This product is intended for research and analytical applications. Abametapir is a metalloproteinase (MMP) inhibitor which is able to target metalloproteinases critical to egg hatching and louse development. Abametapir can inhibit hatching of both head and body louse.
  • HY-120715
    4-Epianhydrochlortetracycline hydrochloride
    		Inhibitor
    4-Epianhydrochlortetracycline hydrochloride is an inhibitor of matrix metalloproteinases (MMPs), particularly gelatinase B (Gelatinase B, EC 3.4.24.35), with inhibition rates of 100% at 500 μg/mL, 70% at 125 μg/mL, and 40% at 31 μg/mL. 4-Epianhydrochlortetracycline hydrochloride is promising for research in chronic inflammatory diseases.
  • HY-19422
    PNU-248686A
    		Inhibitor
    PNU-248686A is a novel matrix metalloproteinase (MMP) inhibitor.
  • HY-43586
    BR351 precursor
    		Inhibitor
    BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively.
  • HY-122585
    proMMP-9 inhibitor-3c
    		Inhibitor
    proMMP-9 inhibitor-3c (compound 3c) is a potent proMMP-9 inhibitor. proMMP-9 inhibitor-3c is specific for binding to the proMMP-9 hemopexin-like domain (Kd=320 nM). proMMP-9 inhibitor-3c disruption of MMP-9 homodimerization prevents association of proMMP-9 with both α4β1 integrin and CD44 and results in the dissociation of EGFR. This disruption results in decreased phosphorylation of Src and its downstream target proteins focal adhesion kinase (FAK) and paxillin (PAX).
  • HY-N13208
    Stevia Powder
    		Inhibitor
    Stevia Powder is a natural sweetener with antioxidant activity. Stevia Powder can downregulate pro fibrotic pathways in cirrhotic rats, including reduced hepatic myofibroblasts and decreased expression of matrix metalloproteinases MMP2 and MMP13, upregulate anti fibrotic molecule Smad7, prevent serum necrosis and elevated bile stasis markers, thereby inhibiting the development of liver fibrosis.
  • HY-W703549
    Aderbasib-d3
    		Inhibitor
    Aderbasib-d3 (INCB007839-d3) is deuterium labeled Aderbasib. Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2+?breast cancer, gliomas, et al.
  • HY-W747703
    Hippuric acid-13C6
    		Inhibitor
    Hippuric acid-13C6 (Benzoylglycine-13C6) is 13C labeled Hippuric acid. Hippuric Acid is an orally active metabolite. Hippuric Acid can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Hippuric Acid decreases NRF2, MMP9 and leads to ROS accumulation. Hippuric Acid activates TGFβ/SMAD signaling. Hippuric Acid improves hyperuricemia and colitis. Hippuric Acid can also be used in cardiovascular disease research. .
  • HY-136885
    (S,S)-TAPI-0
    		Inhibitor
    (S,S)-TAPI-0 is a matrix metalloproteinase (MMP) inhibitor that inhibits the growth of Chlamydia trachomatis by inhibiting PDF enzyme activity. (S,S)-TAPI-0 can be used to study Chlamydia infection.
  • HY-W744160
    Stigmasterol-d6
    		Inhibitor
    Stigmasterol-d6 is deuterium-labeled Stigmasterol (HY-N0131).
  • HY-125568
    Pyridoxatin
    		Inhibitor
    Pyridoxatin is a free radical scavenger of microbial origin. Pyridoxatin is isolated from a fungus culture identified as Acremonium sp. BX86. Pyridoxatin inhibits lipid peroxidation induced by free radicals in rat liver microsomes free from vitamin E.
  • HY-P0273
    Histatin 5
    		Inhibitor
    Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively.