2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W747575
    (+/-)13-HODE cholesteryl ester
    (±)13-HODE cholesteryl ester is originally extracted from atherosclerotic lesions1 and shown to be produced by Cu2+-catalyzed oxidation of LDL. Later studies determined that 15-LO from rabbit reticulocytes and human monocytes were able to metabolize cholesteryl linoleate, a major component of LDL, to 13-HODE cholesteryl ester.
    (+/-)13-HODE cholesteryl ester
  • HY-20685S2
    Palmitoylethanolamide-d5
    Palmitoylethanolamide-d5 (Palmidol-d5, PEA-15,15,16,16,16-d5) is deuterium labeled Palmitoylethanolamide. Palmitoylethanolamide (Palmidrol) is an active endogenous compound which can used for preventing virus infection of the respiratory tract.
    Palmitoylethanolamide-d<sub>5</sub>
  • HY-70037AR
    Cinacalcet (hydrochloride) (Standard)
    Cinacalcet (hydrochloride) (Standard) is the analytical standard of Cinacalcet (hydrochloride). This product is intended for research and analytical applications. Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
    Cinacalcet (hydrochloride) (Standard)
  • HY-113102B
    9(Z),11(Z)-Octadecadienoic acid
    9(Z),11(Z)-octadecadienoic acid is an isomer of linoleic acid and has antitumor activity (EC 50 = 446.1 µM).
    9(Z),11(Z)-Octadecadienoic acid
  • HY-N0455AS9
    L-Arginine-15N4,d7 hydrochloride
    L-Arginine-15N4,d7 (hydrochloride) is the deuterium and 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
    L-Arginine-<sup>15</sup>N<sub>4</sub>,d<sub>7</sub> hydrochloride
  • HY-N13018
    M145724
    M145724 ((3Z,6E)-1-N-Methylalbonoursin) is a metabolite, which can be isolated from Streptomyces albus.
    M145724
  • HY-B0215R
    Acetylcysteine (Standard)
    Acetylcysteine (Standard) is the analytical standard of Acetylcysteine. This product is intended for research and analytical applications. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies.
    Acetylcysteine (Standard)
  • HY-113049
    Phosphoenolpyruvic acid
    Phosphoenolpyruvic acid (Phosphoenolpyruvate) is a biochemical reagent.
    Phosphoenolpyruvic acid
  • HY-N7148A
    (±)-γ-Tocopherol
    (±)-γ-Tocopherol is an endogenous metabolite present in Blood that can be used for the research of Prostate Cancer and Endometrial Cancer.
    (±)-γ-Tocopherol
  • HY-N10346A
    Gluconapin
    Gluconapin is a precursor of sulforaphane, a potent anticancer isothiocyanate. Gluconapin reduces the increase in plasma triglycerides induced by corn oil in mice.
    Gluconapin
  • HY-W702290
    2-Methyldecanenitrile
    2-Methyldecanenitrile is a compound with biological activity for fragrance applications. 2-Methyldecanenitrile exhibits a rich peach aroma with frankincense undertones in perfume compositions. 2-Methyldecanenitrile is stable across the entire pH range, enabling it to create a stable fruity effect at low concentrations in any application.
    2-Methyldecanenitrile
  • HY-114695
    Prostaglandin F2α-1-glyceryl ester
    Prostaglandin F2α-1-glyceryl ester can be oxidized by 15-hydroxyprostaglandin dehydrogenase (15-HPGDH).
    Prostaglandin F2α-1-glyceryl ester
  • HY-W654136
    2'-Deoxycytidine-2'-13C
    2'-Deoxycytidine-2'-13C is 13C labeled 2'-Deoxycytidine. 2'-Deoxycytidine, a deoxyribonucleoside, can inhibit biological effects of Bromodeoxyuridine (Brdu). 2'-Deoxycytidine is essential for the synthesis of nucleic acids, that can be used for the research of cancer.
    2'-Deoxycytidine-2'-<sup>13</sup>C
  • HY-117057S
    Hexaenoic acid-d6
    Hexaenoic acid-d6 is deuterium labeled Hexaenoic acid. Very long chain polyunsaturated fatty acids (VLCPUFAs) are important components of ceramides and sphingomyelin and are present in retina, sperm, and brain. Tetratriaconta-16(Z),19(Z),22(Z),25(Z),28(Z),31(Z)-hexaenoic acid is a C34:6 VLCPUFA whose specific biological actions are largely unknown. This VLCPUFA, along with others, has been investigated for its role in activating protein kinase C.
    Hexaenoic acid-d<sub>6</sub>
  • HY-W030338
    aPKC-IN-2
    aPKC-IN-2 is a small molecule inhibitor that inhibits aPKC activity. aPKC-IN-2 can effectively block vascular endothelial permeability in cell culture and in vivo experiments. aPKC-IN-2 shows biological activity in interfering with NFκB-driven gene transcription and is associated with inflammatory responses. aPKC-IN-2 has a significant inhibitory effect on vascular endothelial permeability induced by VEGF and TNF, and its EC50 value is in the low nanomolar range. The structural characteristics of aPKC-IN-2 reveal key elements of its inhibitory activity, providing the possibility for further development of small molecule aPKC inhibitors.
    aPKC-IN-2
  • HY-B0986R
    Hexylresorcinol (Standard)
    Hexylresorcinol (Standard) is the analytical standard of Hexylresorcinol. This product is intended for research and analytical applications. Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage.
    Hexylresorcinol (Standard)
  • HY-165034
    C18 ((±)-2'-Hydroxy) ceramide (d18:1/18:0)
    C18 ((±)-2'-Hydroxy) ceramide ((±)-2'-Hydroxy) cer) (d18:1/18:0) is a bioactive sphingolipid found in the stratum corneum layer of mammalian epidermis. Ceramides maintains the normal hydration levels required for the normal physiological.
    C18 ((±)-2'-Hydroxy) ceramide (d18:1/18:0)
  • HY-W067425
    2-(4-Hydroxyphenyl)propionic acid
    		≥98.0%
    2-(4-Hydroxyphenyl)propionic acid (Compound 1) is an aromatic carboxylic acid, which can be converted into its R and S glucosyl esters and glucosides by root culture of P. ginseng (Pg-1).
    2-(4-Hydroxyphenyl)propionic acid
  • HY-126598
    Chaetoglobosin F
    Chaetoglobosin F is a cytochalasan-based alkaloid from Chaetomium globosum. Chaetoglobosin F exhibits cytotoxicity against human nasopharyngeal epidermoid tumor cell KB, with IC50 of 52.0 µM.
    Chaetoglobosin F
  • HY-138896
    (9E,11E)-9-Nitro-9,11-octadecadienoic acid
    (9E,11E)-9-Nitro-9,11-octadecadienoic acid (9E,11E-9-Nitro CLA) is a nitro-fatty acid, It is formed by exposure of 9Z, 11E-CLA to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combination of myeloperoxidase, hydrogen peroxide, and nitrite.
    (9E,11E)-9-Nitro-9,11-octadecadienoic acid
Cat. No. Product Name / Synonyms Application Reactivity