aPKC-IN-2

Cat. No.: HY-W030338 Purity: 99.80%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

aPKC-IN-2 is a small molecule inhibitor that inhibits aPKC activity. aPKC-IN-2 can effectively block vascular endothelial permeability in cell culture and in vivo experiments. aPKC-IN-2 shows biological activity in interfering with NFκB-driven gene transcription and is associated with inflammatory responses. aPKC-IN-2 has a significant inhibitory effect on vascular endothelial permeability induced by VEGF and TNF, and its EC₅₀ value is in the low nanomolar range. The structural characteristics of aPKC-IN-2 reveal key elements of its inhibitory activity, providing the possibility for further development of small molecule aPKC inhibitors.

For research use only. We do not sell to patients.

aPKC-IN-2 Chemical Structure

CAS No. : 15854-08-7

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Description

Molecular Weight

261.34

Formula

C₁₄H₁₅NO₂S

CAS No.

15854-08-7

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=C(SC=C1C2=CC=C(C=C2)C)N)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (239.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8264 mL	19.1322 mL	38.2643 mL
5 mM	0.7653 mL	3.8264 mL	7.6529 mL
10 mM	0.3826 mL	1.9132 mL	3.8264 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.80%

Select Batch:

Data Sheet (278 KB) SDS (393 KB)

COA (260 KB) HNMR (247 KB) LCMS (101 KB)

Handling Instructions (2659 KB)

References

[1]. Synthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.8264 mL	19.1322 mL	38.2643 mL	95.6608 mL
	5 mM	0.7653 mL	3.8264 mL	7.6529 mL	19.1322 mL
	10 mM	0.3826 mL	1.9132 mL	3.8264 mL	9.5661 mL
	15 mM	0.2551 mL	1.2755 mL	2.5510 mL	6.3774 mL
	20 mM	0.1913 mL	0.9566 mL	1.9132 mL	4.7830 mL
	25 mM	0.1531 mL	0.7653 mL	1.5306 mL	3.8264 mL
	30 mM	0.1275 mL	0.6377 mL	1.2755 mL	3.1887 mL
	40 mM	0.0957 mL	0.4783 mL	0.9566 mL	2.3915 mL
	50 mM	0.0765 mL	0.3826 mL	0.7653 mL	1.9132 mL
	60 mM	0.0638 mL	0.3189 mL	0.6377 mL	1.5943 mL
	80 mM	0.0478 mL	0.2392 mL	0.4783 mL	1.1958 mL
	100 mM	0.0383 mL	0.1913 mL	0.3826 mL	0.9566 mL

aPKC-IN-2 Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

aPKC-IN-215854-08-7Endogenous MetaboliteInhibitorinhibitorinhibit

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aPKC-IN-2

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