aPKC-IN-2

Cat. No.: HY-W030338: Data Sheet Handling Instructions Technical Support

aPKC-IN-2 is a small molecule inhibitor that inhibits aPKC activity. aPKC-IN-2 can effectively block vascular endothelial permeability in cell culture and in vivo experiments. aPKC-IN-2 shows biological activity in interfering with NFκB-driven gene transcription and is associated with inflammatory responses. aPKC-IN-2 has a significant inhibitory effect on vascular endothelial permeability induced by VEGF and TNF, and its EC₅₀ value is in the low nanomolar range. The structural characteristics of aPKC-IN-2 reveal key elements of its inhibitory activity, providing the possibility for further development of small molecule aPKC inhibitors.

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aPKC-IN-2 Chemical Structure

CAS No. : 15854-08-7

Size	Price	Stock	Quantity
5 mg	USD 47	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	2 - 3 weeks
10 mg	USD 71	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	2 - 3 weeks
25 mg	USD 121	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	2 - 3 weeks
50 mg	USD 180	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	2 - 3 weeks
100 mg		Get quote
200 mg		Get quote

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Description	aPKC-IN-2 is a small molecule inhibitor that inhibits aPKC activity. aPKC-IN-2 can effectively block vascular endothelial permeability in cell culture and in vivo experiments. aPKC-IN-2 shows biological activity in interfering with NFκB-driven gene transcription and is associated with inflammatory responses. aPKC-IN-2 has a significant inhibitory effect on vascular endothelial permeability induced by VEGF and TNF, and its EC₅₀ value is in the low nanomolar range. The structural characteristics of aPKC-IN-2 reveal key elements of its inhibitory activity, providing the possibility for further development of small molecule aPKC inhibitors^[1].
Molecular Weight	261.34
Formula	C₁₄H₁₅NO₂S
CAS No.	15854-08-7
SMILES	O=C(C1=C(SC=C1C2=CC=C(C=C2)C)N)OCC
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (274 KB) Handling Instructions (2659 KB)
References	[1]. Synthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors

aPKC-IN-2 Related Classifications

Inflammation/Immunology

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Keywords:

aPKC-IN-215854-08-7Endogenous MetaboliteInhibitorinhibitorinhibit

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aPKC-IN-2

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