2. Signaling Pathways
  3. MAPK/ERK Pathway
  4. Raf
  5. Raf Degrader

Raf Degrader

Raf Isoform Comparison

Raf Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-153341
    CFT1946
    		Degrader 99.84%
    CFT1946 is an orally active, CRBN-based and mutant-selective bifunctional degradation activating compound (BiDAC™) degrader of BRAFV600E with a DC50 of 14 nM in A375 cells. CFT1946 is capable of degrading BRAF V600E (Class I), G469A (Class II), G466V (Class III) mutations, and the p61-BRAFV600E splice variant. CFT1946 can be used in tumor research.