2. Signaling Pathways
  3. GPCR/G Protein
    MAPK/ERK Pathway
  4. Ras
  5. K-Ras Isoform
  6. K-Ras Antagonist

K-Ras Antagonist

K-Ras Antagonist (1):

Cat. No. Product Name Effect Purity
  • HY-139403
    MRTX849 ethoxypropanoic acid
    		Antagonist
    MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2 (HY-137516). LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (IC50s between 0.25 and 0.76 μM).