2. Signaling Pathways
  3. TGF-beta/Smad
  4. TGF-β Receptor
  5. TGFβR2 Isoform
  6. TGFβR2 Inhibitor

TGFβR2 Inhibitor

TGFβR2 Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-117887
    Fidrisertib
    		Inhibitor
    Fidrisertib (BLU-782) is the orally active inhibitor for activin receptor-like kinase 2 (ALK2) that inhibits ALK2R206H, ALK2, ALK1, ALK6, ALK3, ALK4, TGFβR2 and ALK5 with IC50s of 0.2, 0.6, 3, 24, 45, 65, 67 and 155 nM, respectively.
  • HY-161400
    TGFβRII-IN-2
    		Inhibitor
    TGFβRII-IN-2 (Compound 3n) is an inhibitor for transforming growth factor-β type II receptor (TGFβRII) with IC50 of 2.4 μM, which blocks endothelial-to-mesenchymal transition and cell migration in different cancer cell lines without perturbing the microtubule network.