2. Signaling Pathways
  3. Apoptosis
  4. TNF Receptor
  5. TNFRSF9/4-1BB/CD137 Isoform
  6. TNFRSF9/4-1BB/CD137 Inhibitor

TNFRSF9/4-1BB/CD137 Inhibitor

TNFRSF9/4-1BB/CD137 Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-P99056
    Utomilumab
    		Inhibitor
    Utomilumab (PF 05082566) is a fully human IgG2 mAb agonist of the T-cell costimulatory receptor 4-1BB/CD137. Utomilumab can be used for the research of relapsed/refractory follicular lymphoma (FL) and other CD20+ non-Hodgkin lymphomas (NHL).
  • HY-P99605
    Cinrebafusp alfa
    		Inhibitor 98.53%
    Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research.
  • HY-P99572
    Tecaginlimab
    		Inhibitor 99.00%
    Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of CD40 and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity.