2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. YB-1

YB-1

Y box binding protein 1

YB-1 (Y box binding protein 1) is a multifunctional transcription and translation factor, and is over-expressed in various human cancers. YB-1 is a 36 kDa protein, and consists of three domains: the alanine/proline-rich N-terminal domain (A/P domain), the cold shock domain (CSD), and the large C terminal domain (CTD) with alternating clusters of positively and negatively charged amino acid residues. YB-1 regulates cancer cell proliferation and progression, cell survival, cell proliferation and differentiation, stress response, and malignant cell transformation. YB-1 also participates in a wide variety of DNA/RNA-dependent events, including DNA reparation, pre-mRNA transcription and splicing, mRNA packaging, and regulation of mRNA stability and translation[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-150231
    SU056
    		Inhibitor 99.77%
    SU056 is a YB-1 inhibitor. SU056 induces cell-cycle arrest, apoptosis, and inhibits cell migration in ovarian cancer cells. SU056 interacts with YB-1 and inhibits and its associated downstream proteins and pathways. SU056 can enhance the cytotoxic effects of Paclitaxel (HY-B0015).
    SU056
  • HY-19713
    LJI308
    		Inhibitor 99.07%
    LJI308 is a potent pan-ribosomal S6 kinase (RSK) inhibitor, with IC50s of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. LJI308 inhibits the phosphorylation of RSK (T359/S363) and YB-1 (S102) after irradiation, treatment with EGF, and in cells expressing a KRAS mutation.
    LJI308
  • HY-122920
    Soyasaponin II
    		Inhibitor 99.81%
    Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure.
    Soyasaponin II
  • HY-144434
    RSK-IN-1
    		Inhibitor
    RSK-IN-1 (compound 7d) is a RSK inhibitor that inhibits the YB-1 phosphorylation. RSK-IN-1 has anti-tumor effects.
    RSK-IN-1
Cat. No. Product Name / Synonyms Application Reactivity